2024 heart disease and stroke statistics: a report of US and global data from the American Heart Association
BACKGROUND: The American Heart Association (AHA), in conjunction with the National
Institutes of Health, annually reports the most up-to-date statistics related to heart disease …
Institutes of Health, annually reports the most up-to-date statistics related to heart disease …
Principles and methods for transferring polygenic risk scores across global populations
Polygenic risk scores (PRSs) summarize the genetic predisposition of a complex human trait
or disease and may become a valuable tool for advancing precision medicine. However …
or disease and may become a valuable tool for advancing precision medicine. However …
Heart-brain connections: Phenotypic and genetic insights from magnetic resonance images
Cardiovascular health interacts with cognitive and mental health in complex ways, yet little is
known about the phenotypic and genetic links of heart-brain systems. We quantified heart …
known about the phenotypic and genetic links of heart-brain systems. We quantified heart …
Genetic drivers of heterogeneity in type 2 diabetes pathophysiology
Abstract Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse
pathophysiological processes, and molecular mechanisms that are often specific to cell …
pathophysiological processes, and molecular mechanisms that are often specific to cell …
Development and validation of a trans-ancestry polygenic risk score for type 2 diabetes in diverse populations
T Ge, MR Irvin, A Patki, V Srinivasasainagendra… - Genome Medicine, 2022 - Springer
Abstract Background Type 2 diabetes (T2D) is a worldwide scourge caused by both genetic
and environmental risk factors that disproportionately afflicts communities of color …
and environmental risk factors that disproportionately afflicts communities of color …
Insights from multi-omics integration in complex disease primary tissues
Genome-wide association studies (GWAS) have provided insights into the genetic basis of
complex diseases. In the next step, integrative multi-omics approaches can characterize …
complex diseases. In the next step, integrative multi-omics approaches can characterize …
Association of hypertensive disorders of pregnancy with future cardiovascular disease
B Rayes, M Ardissino, EAW Slob, KHK Patel… - JAMA Network …, 2023 - jamanetwork.com
Importance Hypertensive disorders in pregnancy (HDPs) are major causes of maternal and
fetal morbidity and are observationally associated with future maternal risk of cardiovascular …
fetal morbidity and are observationally associated with future maternal risk of cardiovascular …
Multi-ancestry meta-analysis and fine-mapping in Alzheimer's disease
J Lake, C Warly Solsberg, JJ Kim, J Acosta-Uribe… - Molecular …, 2023 - nature.com
Genome-wide association studies (GWAS) of Alzheimer's disease are predominantly carried
out in European ancestry individuals despite the known variation in genetic architecture and …
out in European ancestry individuals despite the known variation in genetic architecture and …
Genotyping and population characteristics of the China Kadoorie Biobank
RG Walters, IY Millwood, K Lin, DS Valle, P McDonnell… - Cell Genomics, 2023 - cell.com
Summary The China Kadoorie Biobank (CKB) is a population-based prospective cohort of>
512,000 adults recruited from 2004 to 2008 from 10 geographically diverse regions across …
512,000 adults recruited from 2004 to 2008 from 10 geographically diverse regions across …
[HTML][HTML] The Type 2 Diabetes Knowledge Portal: An open access genetic resource dedicated to type 2 diabetes and related traits
MC Costanzo, M von Grotthuss, J Massung, D Jang… - Cell metabolism, 2023 - cell.com
Associations between human genetic variation and clinical phenotypes have become a
foundation of biomedical research. Most repositories of these data seek to be disease …
foundation of biomedical research. Most repositories of these data seek to be disease …