Adipogenic and SWAT cells separate from a common progenitor in human brown and white adipose depots

NP Palani, C Horvath, PN Timshel, P Folkertsma… - Nature …, 2023 - nature.com
Adipocyte function is a major determinant of metabolic disease, warranting investigations of
regulating mechanisms. We show at single-cell resolution that progenitor cells from four …

Density-based detection of cell transition states to construct disparate and bifurcating trajectories

T Lan, G Hutvagner, X Zhang, T Liu… - Nucleic Acids …, 2022 - academic.oup.com
Tree-and linear-shaped cell differentiation trajectories have been widely observed in
developmental biologies and can be also inferred through computational methods from …

De-novo reconstruction and identification of transcriptional gene regulatory network modules differentiating single-cell clusters

M Oubounyt, ML Elkjaer, T Laske… - NAR Genomics and …, 2023 - academic.oup.com
Single-cell RNA sequencing (scRNA-seq) technology provides an unprecedented
opportunity to understand gene functions and interactions at single-cell resolution. While …

AntiSplodge: a neural-network-based RNA-profile deconvolution pipeline designed for spatial transcriptomics

JB Lund, EL Lindberg, H Maatz… - NAR Genomics and …, 2022 - academic.oup.com
With the current surge of spatial transcriptomics (ST) studies, researchers are exploring the
deep interactive cell-play directly in tissues, in situ. However, with the current technologies …

[PDF][PDF] Temporal trajectories of human brown and white adipocyte progenitors at single cell resolution

N Palani, P Timshel, P Folkertsma, A Grønning… - 2022 - pdfs.semanticscholar.org
Adipose tissue type and distribution are major determinants of metabolic disease,
warranting investigations of depot-de ning mechanisms. Here we show that progenitor cells …