Like engineering systems, biological systems must also operate effectively in the presence
of internal and external uncertainty—such as genetic mutations or temperature changes, for …

Robustness, the ability of a system to function correctly in the presence of both internal and
external uncertainty, has emerged as a key organising principle in many biological systems …

Computer simulation offers a fresh approach to traditional medical research that is
particularly well suited to investigating issues related to mechanical ventilation. Patients …

Goal: Machine learning (ML) technologies that leverage large-scale patient data are
promising tools predicting disease evolution in individual patients. However, the limited …

Background Apnoeic oxygenation can come close to matching the oxygen demands of the
apnoeic patient but does not facilitate carbon dioxide (CO 2) elimination, potentially resulting …

Background Clinical trials have, so far, failed to establish clear beneficial outcomes of
recruitment maneuvers (RMs) on patient mortality in acute respiratory distress syndrome …

The selection of mechanical ventilator settings that ensure adequate oxygenation and
carbon dioxide clearance while minimizing the risk of ventilator-associated lung injury (VALI) …

Introduction Direct comparison of the relative efficacy of different recruitment maneuvers
(RMs) for patients with acute respiratory distress syndrome (ARDS) via clinical trials is …

Dear Editor, Mechanical ventilation in paediatric acute respiratory distress syndrome
(PARDS) is less studied than in adults, with guidelines for ventilation adapted from adult …

Mechanical ventilation is a very effective therapy, but with many complications. Simulators
are used in many fields, including medicine, to enhance safety issues. In the intensive care …