Purinergic signalling, ie, the role of nucleotides as extracellular signalling molecules, was
proposed in 1972. However, this concept was not well accepted until the early 1990's when …

Among the various bacterial infections, tuberculosis continues to hold center stage. Its
causative agent, Mycobacterium tuberculosis, possesses robust defense mechanisms …

Two parallel revolutions were born in the golden era of antibiotics (~ 1940 to 1960). One
was a revolution in medicine as physicians went to war with microbes. The second was a …

Increasing antimicrobial resistance compels the search for next-generation inhibitors with
differing or multiple molecular targets. In this regard, energy conservation in Mycobacterium …

The trend toward designing large hydrophobic molecules for lead optimization is often
associated with poor drug-likeness and high attrition rates in drug discovery and …

The genus Mycobacterium comprises a group of obligately aerobic bacteria that have
adapted to inhabit a wide range of intracellular and extracellular environments …

Sulfonamides constitute an important class of drugs, with many types of pharmacological
agents possessing antibacterial, anti-carbonic anhydrase, anti-obesity, diuretic …

Causing approximately 10 million incident cases and 1.3–1.5 million deaths every year,
Mycobacterium tuberculosis remains a global health problem. The risk is further …

There is a constant need for deuterium‐labelled products for multiple applications in life
sciences and beyond. Here, a new class of heterogeneous catalysts is reported for practical …

The F1 FO‐ATP synthase is one of the enzymes that is essential to meet the energy
requirement of both the proliferating aerobic and hypoxic dormant stages of the life cycle of …