Proneural-mesenchymal transition: phenotypic plasticity to acquire multitherapy resistance in glioblastoma

M Fedele, L Cerchia, S Pegoraro, R Sgarra… - International journal of …, 2019 - mdpi.com
Glioblastoma (GBM) is an extremely aggressive tumor of the central nervous system, with a
prognosis of 12–15 months and just 3–5% of survival over 5 years. This is mainly because …

Combination therapy to checkmate Glioblastoma: clinical challenges and advances

D Ghosh, S Nandi, S Bhattacharjee - Clinical and translational medicine, 2018 - Springer
Combination therapy is increasingly becoming the cornerstone of current day antitumor
therapy. Glioblastoma multiforme is an aggressive brain tumor with a dismal median survival …

Facile synthesis of Fe3O4@ MIL-100 (Fe) towards enhancing photo-Fenton like degradation of levofloxacin via a synergistic effect between Fe3O4 and MIL-100 (Fe)

W He, Z Li, S Lv, M Niu, W Zhou, J Li, R Lu… - Chemical Engineering …, 2021 - Elsevier
Abstract The Fe 3 O 4@ MIL-100 (Fe) hybrid composites are successfully synthesized via an
in-situ growth method and characterized using various techniques. The ability of the …

The adaptive transition of glioblastoma stem cells and its implications on treatments

Z Wang, H Zhang, S Xu, Z Liu, Q Cheng - Signal transduction and …, 2021 - nature.com
Glioblastoma is the most malignant tumor occurring in the human central nervous system
with overall median survival time< 14.6 months. Current treatments such as chemotherapy …

Developments in blood-brain barrier penetrance and drug repurposing for improved treatment of glioblastoma

BG Harder, MR Blomquist, J Wang, AJ Kim… - Frontiers in …, 2018 - frontiersin.org
Glioblastoma (GBM) is one of the most common, deadly, and difficult-to-treat adult brain
tumors. Surgical removal of the tumor, followed by radiotherapy (RT) and temozolomide …

Glioblastoma Stem-Like Cells, Metabolic Strategy to Kill a Challenging Target

D Garnier, O Renoult, MC Alves-Guerra, F Paris… - Frontiers in …, 2019 - frontiersin.org
Over the years, substantial evidence has definitively confirmed the existence of cancer stem-
like cells within tumors such as Glioblastoma (GBM). The importance of Glioblastoma stem …

[HTML][HTML] Inhibition of mitochondrial translation suppresses glioblastoma stem cell growth

D Sighel, M Notarangelo, S Aibara, A Re, G Ricci… - Cell reports, 2021 - cell.com
Glioblastoma stem cells (GSCs) resist current glioblastoma (GBM) therapies. GSCs rely
highly on oxidative phosphorylation (OXPHOS), whose function requires mitochondrial …

Diagnosis and management of glioblastoma: A comprehensive perspective

V Gilard, A Tebani, I Dabaj, A Laquerrière… - Journal of personalized …, 2021 - mdpi.com
Glioblastoma is the most common malignant brain tumor in adults. The current management
relies on surgical resection and adjuvant radiotherapy and chemotherapy. Despite …

Glioblastoma's next top model: novel culture systems for brain cancer radiotherapy research

S Caragher, AJ Chalmers, N Gomez-Roman - Cancers, 2019 - mdpi.com
Glioblastoma (GBM), the most common and aggressive primary brain tumor in adults,
remains one of the least treatable cancers. Current standard of care—combining surgical …

[HTML][HTML] Interest of integrins targeting in glioblastoma according to tumor heterogeneity and cancer stem cell paradigm: an update

L Malric, S Monferran, J Gilhodes, S Boyrie, P Dahan… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Glioblastomas are malignant brain tumors with dismal prognosis despite standard treatment
with surgery and radio/chemotherapy. These tumors are defined by an important cellular …