When the cloning era arrived, our first target for cloning was the δ1-crystallin gene of the
chicken, the lens-specific gene expressed earliest following lens induction. We have …

Gli family zinc finger proteins are mediators of Sonic hedgehog (Shh) signaling in
vertebrates. The question remains unanswered, however, as to how these Gli proteins …

The dynamic process of cell fate specification is regulated by networks of regulatory genes.
The architecture of the network defines the temporal order of specification events. To …

Balancing signals derived from the TGFβ family is crucial for regulating cell proliferation and
differentiation, and in establishing the embryonic axis during development. TGFβ/BMP …

Sox2 expression marks neural and sensory primordia at various stages of development. A
50 kb genomic region of chicken Sox2 was isolated and scanned for enhancer activity …

Binding of TGFβ/BMP factors to their receptors leads to translocation of Smad proteins to the
nucleus where they activate transcription of target genes. The two‐handed zinc finger …

Group B Sox genes, Sox1,-2 and-3 are known to activate crystallin genes and to be involved
in differentiation of lens and neural tissues. Screening of chicken genomic sequences for …

ABSTRACT δEF1 is a DNA binding protein containing a homeodomain and two zinc finger
clusters, and is regarded as a vertebrate homologue of zfh-1 (z inc finger h omeodomain …

The ZEB family of transcription factors regulates key factors during embryonic development
and cell differentiation but their role in cancer biology has only more recently begun to be …

SIP1, a Smad‐interacting protein, and δEF1, a transcriptional repressor involved in skeletal
and T‐cell development, belong to the same family of DNA binding proteins. SIP1 and δEF1 …