[PDF][PDF] Interplay of Pax6 and SOX2 in lens development as a paradigm of genetic switch mechanisms for cell differentiation
H Kondoh, M Uchikawa… - International Journal of …, 2004 - scholar.archive.org
When the cloning era arrived, our first target for cloning was the δ1-crystallin gene of the
chicken, the lens-specific gene expressed earliest following lens induction. We have …
chicken, the lens-specific gene expressed earliest following lens induction. We have …
Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: implication of Gli2 and Gli3 as primary mediators of Shh signaling
Gli family zinc finger proteins are mediators of Sonic hedgehog (Shh) signaling in
vertebrates. The question remains unanswered, however, as to how these Gli proteins …
vertebrates. The question remains unanswered, however, as to how these Gli proteins …
[HTML][HTML] Modeling the dynamics of transcriptional gene regulatory networks for animal development
SBT de-Leon, EH Davidson - Developmental biology, 2009 - Elsevier
The dynamic process of cell fate specification is regulated by networks of regulatory genes.
The architecture of the network defines the temporal order of specification events. To …
The architecture of the network defines the temporal order of specification events. To …
[HTML][HTML] Regulation of Smad signaling through a differential recruitment of coactivators and corepressors by ZEB proteins
AA Postigo, JL Depp, JJ Taylor, KL Kroll - The EMBO journal, 2003 - embopress.org
Balancing signals derived from the TGFβ family is crucial for regulating cell proliferation and
differentiation, and in establishing the embryonic axis during development. TGFβ/BMP …
differentiation, and in establishing the embryonic axis during development. TGFβ/BMP …
[HTML][HTML] Functional analysis of chicken Sox2 enhancers highlights an array of diverse regulatory elements that are conserved in mammals
Sox2 expression marks neural and sensory primordia at various stages of development. A
50 kb genomic region of chicken Sox2 was isolated and scanned for enhancer activity …
50 kb genomic region of chicken Sox2 was isolated and scanned for enhancer activity …
[HTML][HTML] Opposing functions of ZEB proteins in the regulation of the TGFβ/BMP signaling pathway
AA Postigo - The EMBO journal, 2003 - embopress.org
Binding of TGFβ/BMP factors to their receptors leads to translocation of Smad proteins to the
nucleus where they activate transcription of target genes. The two‐handed zinc finger …
nucleus where they activate transcription of target genes. The two‐handed zinc finger …
[HTML][HTML] Two distinct subgroups of Group B Sox genes for transcriptional activators and repressors: their expression during embryonic organogenesis of the chicken
M Uchikawa, Y Kamachi, H Kondoh - Mechanisms of development, 1999 - Elsevier
Group B Sox genes, Sox1,-2 and-3 are known to activate crystallin genes and to be involved
in differentiation of lens and neural tissues. Screening of chicken genomic sequences for …
in differentiation of lens and neural tissues. Screening of chicken genomic sequences for …
δEF1, a zinc finger and homeodomain transcription factor, is required for skeleton patterning in multiple lineages
T Takagi, H Moribe, H Kondoh, Y Higashi - Development, 1998 - journals.biologists.com
ABSTRACT δEF1 is a DNA binding protein containing a homeodomain and two zinc finger
clusters, and is regarded as a vertebrate homologue of zfh-1 (z inc finger h omeodomain …
clusters, and is regarded as a vertebrate homologue of zfh-1 (z inc finger h omeodomain …
[HTML][HTML] Expanding roles of ZEB factors in tumorigenesis and tumor progression
E Sánchez-Tilló, L Siles, O De Barrios… - American journal of …, 2011 - ncbi.nlm.nih.gov
The ZEB family of transcription factors regulates key factors during embryonic development
and cell differentiation but their role in cancer biology has only more recently begun to be …
and cell differentiation but their role in cancer biology has only more recently begun to be …
[HTML][HTML] New mode of DNA binding of multi‐zinc finger transcription factors: δEF1 family members bind with two hands to two target sites
JE Remacle, H Kraft, W Lerchner, G Wuytens… - The EMBO …, 1999 - embopress.org
SIP1, a Smad‐interacting protein, and δEF1, a transcriptional repressor involved in skeletal
and T‐cell development, belong to the same family of DNA binding proteins. SIP1 and δEF1 …
and T‐cell development, belong to the same family of DNA binding proteins. SIP1 and δEF1 …