Mortality among patients with chronic kidney disease (CKD) is largely a consequence of
cardiovascular disease (CVD) and is a particular concern given the increasing prevalence of …

Inflammasomes are multiprotein innate immune complexes that regulate caspase-
dependent inflammation and cell death. Pattern recognition receptors, such as nucleotide …

Inflammation with macrophage infiltration is a key feature of atherosclerosis. Although the
mechanisms had been unclear, emerging evidence unveiled that NLRP3 inflammasomes …

Kidney injury implies danger signaling and a response by the immune system. The
inflammasome is a central danger recognition platform that triggers local and systemic …

Rhabdomyolysis is a severe condition that commonly leads to acute kidney injury (AKI).
While double-stranded DNA (dsDNA) released from injured muscle can be involved in its …

Objective—Inflammation provoked by the imbalance of fatty acid composition, such as
excess saturated fatty acids (SFAs), is implicated in the development of metabolic diseases …

Heart failure is a complex clinical syndrome characterized by insufficient cardiac function. In
addition to abnormalities intrinsic to the heart, dysfunction of other organs and dysregulation …

Nonmicrobial inflammation contributes to CKD progression and fibrosis. Absent in
melanoma 2 (AIM2) is an inflammasome-forming receptor for double-stranded DNA. AIM2 is …

The nucleotide-binding oligomerization domain–like receptor family pyrin domain containing
3 (NLRP3) inflammasome is a molecular platform that induces caspase-1 activation and …

Background Gentamicin is a potent aminoglycoside antibiotic that targets gram-negative
bacteria, but nephrotoxicity limits its clinical application. The cause of gentamicin-induced …