Bifunctional degrader molecules, also called proteolysis-targeting chimeras (PROTACs), are
a new modality of chemical tools and potential therapeutics to understand and treat human …

Conspectus Although macrocyclic peptides bearing exotic building blocks have proven their
utility as pharmaceuticals, the sources of macrocyclic peptide drugs have been largely …

As a versatile therapeutic modality, peptides attract much attention because of their great
binding affinity, low toxicity, and the capability of targeting traditionally “undruggable” protein …

Macrocyclic peptides represent attractive scaffolds for targeting protein–protein interactions,
making methods for the diversification and functional selection of these molecules highly …

Conspectus Chemical manipulation of naturally occurring peptides offers a convenient route
for generating analogs to screen against different therapeutic targets. However, the limited …

Adenosine triphosphate-binding cassette (ABC) transporters, such as multidrug resistance
protein 1 (MRP1), protect against cellular toxicity by exporting xenobiotic compounds across …

mRNA display is a robust in vitro selection technique that allows the selection of peptides
and proteins with desired functions from libraries of trillions of variants. mRNA display relies …

Intracellular protein–protein interactions (PPIs) are challenging targets for traditional drug
modalities. Macrocyclic peptides (MPs) prove highly effective PPI inhibitors in vitro and can …

Glycosyltransferases are a superfamily of enzymes that are notoriously difficult to inhibit.
Here we apply an mRNA display technology integrated with genetic code reprogramming …

The COVID-19 pandemic, caused by SARS-CoV-2, has led to substantial morbidity,
mortality, and disruption globally. Cellular entry of SARS-CoV-2 is mediated by the viral …