In precision oncology, two major strategies are being pursued for predicting clinically
relevant tumour behaviours, such as treatment response and emergence of drug resistance …

Despite the pre-eminence of the mouse in modelling human disease, several aspects of
murine biology limit its routine use in large-scale genetic and therapeutic screening. Many …

Clonal hematopoiesis results from enhanced fitness of a mutant hematopoietic stem and
progenitor cell (HSPC), but how such clones expand is unclear. We developed a technique …

The widespread availability of programmable site-specific nucleases now enables targeted
gene disruption in the zebrafish. In this study, we applied site-specific nucleases to generate …

Vessel sprouting by migrating tip and proliferating stalk endothelial cells (ECs) is controlled
by genetic signals (such as Notch), but it is unknown whether metabolism also regulates this …

The limited per-pixel bandwidth of most microscopy methods requires compromises
between field of view, sampling density and imaging speed. This limitation constrains …

The zebrafish (Danio rerio) is increasingly being used to study basic vertebrate biology and
human disease with a rich array of in vivo genetic and molecular tools. However, the inability …

The attenuation of ancestral pro-regenerative pathways may explain why humans do not
efficiently regenerate damaged organs. Vertebrate lineages that exhibit robust regeneration …

A major goal of regenerative medicine is to instruct formation of multipotent, tissue-specific
stem cells from induced pluripotent stem cells (iPSCs) for cell replacement therapies …

Hematopoietic stem and progenitor cells (HSPCs) can reconstitute and sustain the entire
blood system. We generated a highly specific transgenic reporter of HSPCs in zebrafish …