The evolution of small molecule enzyme activators
LF Dow, AM Case, MP Paustian, BR Pinkerton… - RSC Medicinal …, 2023 - pubs.rsc.org
There is a myriad of enzymes within the body responsible for maintaining homeostasis by
providing the means to convert substrates to products as and when required. Physiological …
providing the means to convert substrates to products as and when required. Physiological …
Hijacking Chemical Reactions of P450 Enzymes for Altered Chemical Reactions and Asymmetric Synthesis
E Rajakumara, D Saniya, P Bajaj… - International journal of …, 2022 - mdpi.com
Cytochrome P450s are heme-containing enzymes capable of the oxidative transformation of
a wide range of organic substrates. A protein scaffold that coordinates the heme iron, and …
a wide range of organic substrates. A protein scaffold that coordinates the heme iron, and …
Unraveling the mechanism of small molecule induced activation of Staphylococcus aureus signal peptidase IB
SY Chen, MK Fiedler, TF Gronauer, O Omelko… - Communications …, 2024 - nature.com
Staphylococcus aureus signal peptidase IB (SpsB) is an essential enzyme for protein
secretion. While inhibition of its activity by small molecules is a well-precedented …
secretion. While inhibition of its activity by small molecules is a well-precedented …
Rhizobacteria-priming improves common bean seeds germination under different abiotic stresses through improving hydrolysis and antioxidant enzymes kinetics …
LYA Al Hijab, NE Al-Hazmi, DM Naguib - Rhizosphere, 2024 - Elsevier
Bio-priming is a proven method for enhancing seed germination in stressful environments.
Researchers have thoroughly explored its impact on enzyme activity during seed …
Researchers have thoroughly explored its impact on enzyme activity during seed …
Synthesis, activatory effects, molecular docking and ADME studies as rabbit muscle pyruvate kinase activators of ureido phenyl substituted 1, 4-dihydropyridine …
In this study, the activation of pyruvate kinase enzyme in vitro via different urea substituents
in the para position as functional groups of 1, 4-dihydropyridine derivatives synthesized by …
in the para position as functional groups of 1, 4-dihydropyridine derivatives synthesized by …
Can Activation of Acetylcholinesterase by β-Amyloid Peptide Decrease the Effectiveness of Cholinesterase Inhibitors?
IV Zueva, EA Vasilieva, GA Gaynanova… - International Journal of …, 2023 - mdpi.com
A central event in the pathogenesis of Alzheimer's disease (AD) is the accumulation of
senile plaques composed of aggregated amyloid-β (Aβ) peptides. The main class of drugs …
senile plaques composed of aggregated amyloid-β (Aβ) peptides. The main class of drugs …
Thermodynamically-consistent, reduced models of gene regulatory networks
Synthetic biology aims to engineer novel functionalities into biological systems. While the
approach has been widely applied to single cells, the scale of synthetic circuits designed in …
approach has been widely applied to single cells, the scale of synthetic circuits designed in …