Much evidence has accumulated in the literature over the last fifteen years that indicates
vitamin A has a role in metabolic disease prevention and causation. This literature proposes …

Liver fibrosis is a regenerative process that occurs after injury. It is characterized by the
deposition of connective tissue by specialized fibroblasts and concomitant proliferative …

Retinoids (vitamin A) are crucial for most forms of life. In chordates, they have important roles
in the developing nervous system and notochord and many other embryonic structures, as …

Hepatic lipocytes were isolated from normal rat liver and established in culture. A virtually
pure isolate was obtained by fractionating enzymatically digested liver on a discontinuous …

The requirement of vitamin A (retinoids) for vision has been recognized for decades. In
addition, vitamin A is involved in fetal development and in the regulation of proliferation and …

Metabolic processes utilize a variety of differing and contrasting biochemical routes to
enable synthesis of degradation and activation or deactivation of substances; in addition …

Vitamin A (retinol) is a critical micronutrient required for the control of stem cell functions, cell
differentiation, and cell metabolism in many different cell types, both during embryogenesis …

Introduction T HE transport of retinol (vitamin A alcohol) from retinoid (vitamin A and its
analogs) stores in the liver to target tissues is accomplished exclusively by means of a …

It is well established that chylomicron remnant (dietary) vitamin A is taken up from the
circulation by hepatocytes, but more than 80% of the vitamin A in the liver is stored in hepatic …

Transthyretin (TTR) is thought to play a major role in vitamin A metabolism and thyroid
hormone transport in mammals. To investigate the physiological role of the TTR protein in …