The previous edition of the consensus guidelines of the International Workshop on Chronic
Lymphocytic Leukemia (iwCLL), published in 2008, has found broad acceptance by …

Our concept of the pathogenesis of chronic lymphocytic leukemia has undergone
remarkable changes during the past decade. This review addresses the latest ideas …

Cellular immunophenotypic studies were performed on a cohort of randomly selected IgM+
B-chronic lymphocytic leukemia (B-CLL) cases for which Ig VH and VL gene sequences …

Mounting evidence indicates that grouping of chronic lymphocytic leukemia (CLL) into
distinct subsets with stereotyped BCRs is functionally and prognostically relevant. However …

Chronic lymphocytic leukaemia (CLL) has several unique features that distinguish it from
other cancers. Most CLL tumour cells are inert and arrested in G0/G1 of the cell cycle and …

To better understand the stage (s) of differentiation reached by B-type chronic lymphocytic
leukemia (B-CLL) cells and to gain insight into the potential role of antigenic stimulation in …

During the past 5 years, a number of highly active novel agents, including kinase inhibitors
targeting BTK or PI3Kδ, an antagonist of the antiapoptotic protein BCL-2, and new anti …

The discovery of almost identical or 'stereotyped'B-cell receptor immunoglobulins (BcR IG)
among unrelated patients with chronic lymphocytic leukemia (CLL) cemented the idea of …

Pivotal studies from the 1990s offered the first pieces of evidence for the role of
immunoglobulin (IG) receptors and antigen stimulation in the natural history of chronic …

B cell chronic lymphocytic leukemia (B-CLL) is an accumulative disease of slowly
proliferating CD5+ B lymphocytes that develops in the aging population. Whereas some …