ADP-ribosylation (ADPRylation) is a post-translational modification of proteins catalyzed by
ADP-ribosyl transferase (ART) enzymes, including nuclear PARPs (eg, PARP1 and PARP2) …

Sirtuins are a family of proteins with enzymatic activity. There are seven mammalian sirtuins
(SIRT1-SIRT7) that are found in different cellular compartments. They are a part of crucial …

PARP1, an established anti-cancer target that regulates many cellular pathways, including
DNA repair signaling, has been intensely studied for decades as a poly (ADP-ribosyl) …

Poly ADP-ribosylation (PARylation) is a post-translational modification process. Following
the discovery of PARP-1, numerous studies have demonstrated the role of PARylation in the …

The DNA damage response (DDR) ensures error-free DNA replication and transcription and
is disrupted in numerous diseases. An ongoing challenge is to determine the proteins …

Poly (ADP-ribose) polymerase 1 (PARP1) is a key DNA damage sensor that is recruited to
damaged sites after DNA strand breaks to initiate DNA repair. This is achieved by catalyzing …

ADP-ribosylation (ADPr) is a widespread post-translational modification (PTM) which
encompasses all kingdoms of life. It is employed by bacteria and viruses in their war against …

SIRT6 is an NAD+ dependent deacetylase that belongs to the mammalian sirtuin family.
SIRT6 is mainly located in the nucleus and regulates chromatin remodeling, genome …

Base excision repair (BER) is carried out by a series of proteins that function in a step-by-
step process to identify, remove, and replace DNA damage. During BER, the DNA …

Elevated expression of the DNA damage response proteins PARP1 and poly (ADP-ribose)
glycohydrolase (PARG) in glioma stem cells (GSCs) suggests that glioma may be a unique …