Traumatic injuries of the central nervous system (CNS) affect millions of people worldwide,
and they can lead to severely damaging consequences such as permanent disability and …

Neutrophils are short-lived cells of the innate immune system and the first line of defense at
the site of an infection and tissue injury. Pattern recognition receptors on neutrophils …

The role of inflammation in nervous system injury and disease is attracting increased
attention. Much of that research has focused on microglia in the central nervous system …

Aim Apoptosis of endothelial cells (ECs) is a crucial factor in blood-spinal cord barrier
(BSCB) disruption post spinal cord injury (SCI). Insulin-like growth factor-1 (IGF-1) is a …

Around 20% of the American population have chronic pain and estimates in other Western
countries report similar numbers. This represents a major challenge for global health care …

Spinal cord injury (SCI) is a devastating condition of the central nervous system that can
lead to permanent motor and sensory deficits. Carbon monoxide–releasing molecule-2 …

Background Spinal cord injury (SCI) is a common disease that results in motor and sensory
disorders and even lifelong paralysis. The transplantation of stem cells, such as embryonic …

Regeneration is bungled following CNS injuries, including spinal cord injury (SCI). Inherent
decay of permissive conditions restricts the regrowth of the mature CNS after an injury …

Secondary pathogenesis following primary mechanical damage to the spinal cord is
believed to be the ultimate reason for the limitation of currently available therapies …

Low back pain following spine surgery is a major complication due to excessive epidural
fibrosis, which compresses the lumbar nerve. The mechanisms of epidural fibrosis remain …