It's getting complicated—a fresh look at p53-MDM2-ARF triangle in tumorigenesis and cancer therapy
Anti-tumorigenic mechanisms mediated by the tumor suppressor p53, upon oncogenic
stresses, are our bodies' greatest weapons to battle against cancer onset and development …
stresses, are our bodies' greatest weapons to battle against cancer onset and development …
[HTML][HTML] Mutations of p53 associated with pancreatic cancer and therapeutic implications
IA Voutsadakis - Annals of hepato-biliary-pancreatic surgery, 2021 - synapse.koreamed.org
Pancreatic adenocarcinoma is a malignancy with rising incidence and grim prognosis.
Despite improvements in therapeutics for treating metastatic pancreatic cancer, this disease …
Despite improvements in therapeutics for treating metastatic pancreatic cancer, this disease …
NRF2 is a major target of ARF in p53-independent tumor suppression
Although ARF can suppress tumor growth by activating p53 function, the mechanisms by
which it suppresses tumor growth independently of p53 are not well understood. Here, we …
which it suppresses tumor growth independently of p53 are not well understood. Here, we …
Deciphering DNA methylation signatures of pancreatic cancer and pancreatitis
Background Chronic pancreatitis presents a high risk of inflammation-related progression to
pancreatic cancer. Pancreatic cancer is the fourth leading cause of cancer-related death …
pancreatic cancer. Pancreatic cancer is the fourth leading cause of cancer-related death …
C-terminal binding proteins: central players in development and disease
TR Stankiewicz, JJ Gray, AN Winter… - Biomolecular …, 2014 - degruyter.com
C-terminal binding proteins (CtBPs) were initially identified as binding partners for the E1A-
transforming proteins. Although the invertebrate genome encodes one CtBP protein, two …
transforming proteins. Although the invertebrate genome encodes one CtBP protein, two …
Molecular pathology of pancreatic cancer
Y Saiki, A Horii - Pathology international, 2014 - Wiley Online Library
By genomic and epigenomic screening techniques, substantial progress has been made in
our understanding of pancreatic cancer. The comprehensive studies of the pancreatic …
our understanding of pancreatic cancer. The comprehensive studies of the pancreatic …
Dual role of the alternative reading frame ARF protein in cancer
The CDKN2a/ARF locus expresses two partially overlapping transcripts that encode two
distinct proteins, namely p14ARF (p19Arf in mouse) and p16INK4a, which present no …
distinct proteins, namely p14ARF (p19Arf in mouse) and p16INK4a, which present no …
Phenotypic heterogeneity and plasticity of cancer cell migration in a pancreatic tumor three-dimensional culture model
Invasive cancer cell migration is a key feature of metastatic human pancreatic ductal
adenocarcinoma (PDAC), yet the underlying mechanisms remain poorly understood. Here …
adenocarcinoma (PDAC), yet the underlying mechanisms remain poorly understood. Here …
Pharmacological ascorbate inhibits pancreatic cancer metastases via a peroxide-mediated mechanism
BR O'Leary, MS Alexander, J Du, DL Moose… - Scientific reports, 2020 - nature.com
Abstract Pharmacological ascorbate (P-AscH−, high-dose, intravenous vitamin C) is
cytotoxic to tumor cells in doses achievable in humans. Phase I studies in pancreatic cancer …
cytotoxic to tumor cells in doses achievable in humans. Phase I studies in pancreatic cancer …
Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis
Abstract Anterior gradient 2 (AGR2) is a member of the protein disulfide isomerase (PDI)
family, which plays a role in the regulation of protein homeostasis and the unfolded protein …
family, which plays a role in the regulation of protein homeostasis and the unfolded protein …