The amyloid hypothesis (AH) of Alzheimer's disease (AD) posits that the fundamental cause
of AD is the accumulation of the peptide amyloid beta (Aβ) in the brain. This hypothesis has …

In the central nervous system (CNS) of most vertebrates, oligodendrocytes enwrap neuronal
axons with extensions of their plasma membrane to form the myelin sheath. Several proteins …

Proteins are dynamic creatures. Intrinsically disordered proteins (IDPs) function as
multiplicity of structures and their activities can only be described by stochastic structure …

The classic myelin basic protein (MBP) splice isoforms range in nominal molecular mass
from 14 to 21.5 kDa, and arise from the gene in the oligodendrocyte lineage (Golli) in …

Oligodendrocytes, the myelin‐forming cells of the central nervous system, are in culture
characterized by an elaborate process network, terminating in flat membranous sheets that …

Myelin basic protein (MBP) binds to negatively charged lipids on the cytosolic surface of
oligodendrocyte membranes and is responsible for adhesion of these surfaces in the …

The classic isoforms of myelin basic protein (MBP, 14–21.5 kDa) are essential to formation
of the multilamellar myelin sheath of the mammalian central nervous system (CNS). The …

Microtubule‐associated protein Tau is primarily expressed in axons of neurons, but also in
Olig2‐positive oligodendrocytes in adult rodent and monkey brains. In this study, we sought …

Oligodendrocytes, the myelin forming cells of the CNS, are characterized by their numerous
membranous extensions, which enwrap neuronal axons and form myelin sheaths. During …

In the progressive phase of multiple sclerosis (MS), the hampered differentiation capacity of
oligodendrocyte precursor cells (OPCs) eventually results in remyelination failure. We have …