Targeting of the tumor immune microenvironment by metformin
Z Wu, C Zhang, M Najafi - Journal of cell communication and signaling, 2022 - Springer
Stimulating antitumor immunity is an attractive idea for suppressing tumors. CD4+ and CD8+
T cells as well as natural killer cells (NK) are the primary antitumor immune cells in the tumor …
T cells as well as natural killer cells (NK) are the primary antitumor immune cells in the tumor …
[HTML][HTML] A clinical perspective of the multifaceted mechanism of metformin in diabetes, infections, cognitive dysfunction, and cancer
In type 2 diabetes, ecological and lifecourse factors may interact with the host microbiota to
influence expression of his/her genomes causing perturbation of interconnecting biological …
influence expression of his/her genomes causing perturbation of interconnecting biological …
[HTML][HTML] Relaxin-encapsulated polymeric metformin nanoparticles remodel tumor immune microenvironment by reducing CAFs for efficient triple-negative breast …
H Zhang, L Chen, Y Zhao, N Luo, J Shi, S Xu… - Asian journal of …, 2023 - Elsevier
Cancer-associated fibroblasts (CAFs) are one of the most abundant stromal cells in the
tumor microenvironment which mediate desmoplastic response and are the primary driver …
tumor microenvironment which mediate desmoplastic response and are the primary driver …
[HTML][HTML] Advancing immune checkpoint blockade in colorectal cancer therapy with nanotechnology
Z Liu, Y Xiang, Y Zheng, X Kang - Frontiers in immunology, 2022 - frontiersin.org
Immune checkpoint blockade (ICB) has gained unparalleled success in the treatment of
colorectal cancer (CRC). However, undesired side effects, unsatisfactory response rates …
colorectal cancer (CRC). However, undesired side effects, unsatisfactory response rates …
Reversing multi-drug resistance by polymeric metformin to enhance antitumor efficacy of chemotherapy
H Zhang, J Yu, L Ma, Y Zhao, S Xu, J Shi, K Qian… - International Journal of …, 2022 - Elsevier
Multi-drug resistance (MDR) in breast cancer poses a great threat to chemotherapy. The
expression and function of the ATP binding cassette (ABC) transporter are the major cause …
expression and function of the ATP binding cassette (ABC) transporter are the major cause …