The role of hydrogen sulfide in evolution and the evolution of hydrogen sulfide in metabolism and signaling

KR Olson, KD Straub - Physiology, 2016 - journals.physiology.org
The chemical versatility of sulfur and its abundance in the prebiotic Earth as reduced sulfide
(H2S) implicate this molecule in the origin of life 3.8 billion years ago and also as a major …

Antioxidant and cell‐signaling functions of hydrogen sulfide in the central nervous system

U Shefa, MS Kim, NY Jeong… - Oxidative medicine and …, 2018 - Wiley Online Library
Hydrogen sulfide (H2S), a toxic gaseous molecule, plays a physiological role in regulating
homeostasis and cell signaling. H2S is produced from cysteine by enzymes, such as …

[HTML][HTML] Cerebrospinal fluid proteomics define the natural history of autosomal dominant Alzheimer's disease

ECB Johnson, S Bian, RU Haque, EK Carter… - Nature medicine, 2023 - nature.com
Alzheimer's disease (AD) pathology develops many years before the onset of cognitive
symptoms. Two pathological processes—aggregation of the amyloid-β (Aβ) peptide into …

Hydrogen sulfide, reactive sulfur species and coping with reactive oxygen species

KR Olson - Free Radical Biology and Medicine, 2019 - Elsevier
Life began in a ferruginous (anoxic and Fe 2+ dominated) world around 3.8 billion years ago
(bya). Hydrogen sulfide (H 2 S) and other sulfur molecules from hydrothermal vents and …

Physiological importance of hydrogen sulfide: emerging potent neuroprotector and neuromodulator

S Panthi, HJ Chung, J Jung… - Oxidative Medicine and …, 2016 - Wiley Online Library
Hydrogen sulfide (H2S) is an emerging neuromodulator that is considered to be a
gasotransmitter similar to nitrogen oxide (NO) and carbon monoxide (CO). H2S exerts …

[HTML][HTML] An overview of the involvement of d-serine in cognitive impairment in normal aging and dementia

M Orzylowski, E Fujiwara, DD Mousseau… - Frontiers in …, 2021 - frontiersin.org
Dementia, of which Alzheimer's disease (AD) is the most common form, is characterized by
progressive cognitive deterioration, including profound memory loss, which affects …

[HTML][HTML] Advances in D-amino acids in neurological research

JM Seckler, SJ Lewis - International journal of molecular sciences, 2020 - mdpi.com
D-amino acids have been known to exist in the human brain for nearly 40 years, and they
continue to be a field of active study to today. This review article aims to give a concise …

Hydrogen sulfide in physiological and pathological mechanisms in brain

M Kumar, R Sandhir - … (Formerly Current Drug Targets-CNS & …, 2018 - ingentaconnect.com
Background & Objective: Hydrogen sulfide [H2S] has been widely known as a toxic gas for
more than 300 years in the scientific community. However, the understanding about this …

[HTML][HTML] Hydrogen sulfide and its donors for the treatment of cerebral ischaemia-reperfusion injury: A comprehensive review

Y Huang, M Omorou, M Gao, C Mu, W Xu… - Biomedicine & …, 2023 - Elsevier
As an endogenous gas signalling molecule, hydrogen sulfide (H 2 S) is frequently present in
a variety of mammals and plays a significant role in the cardiovascular and nervous systems …

Supramolecular Activation of S8 by Cucurbiturils in Water and Mechanism of Reduction to H2S by Thiols: Insights into Biological Sulfane Sulfur Trafficking

AC Garcia, LN Zakharov, MD Pluth - Journal of the American …, 2022 - ACS Publications
Reactive sulfur species (RSS) play critical roles in diverse chemical environments.
Molecules containing sulfane sulfur (S0) have emerged as key species involved in cellular …