The ecology and evolutionary dynamics of meiotic drive
Meiotic drivers are genetic variants that selfishly manipulate the production of gametes to
increase their own rate of transmission, often to the detriment of the rest of the genome and …
increase their own rate of transmission, often to the detriment of the rest of the genome and …
Meiosis: the chromosomal foundation of reproduction
E Bolcun-Filas, MA Handel - Biology of reproduction, 2018 - academic.oup.com
Meiosis is the chromosomal foundation of reproduction, with errors in this important process
leading to aneuploidy and/or infertility. In this review celebrating the 50th anniversary of the …
leading to aneuploidy and/or infertility. In this review celebrating the 50th anniversary of the …
Genomes of the mouse collaborative cross
Abstract The Collaborative Cross (CC) is a multiparent panel of recombinant inbred (RI)
mouse strains derived from eight founder laboratory strains. RI panels are popular because …
mouse strains derived from eight founder laboratory strains. RI panels are popular because …
The mouse universal genotyping array: from substrains to subspecies
Genotyping microarrays are an important resource for genetic mapping, population genetics,
and monitoring of the genetic integrity of laboratory stocks. We have developed the third …
and monitoring of the genetic integrity of laboratory stocks. We have developed the third …
Spindle asymmetry drives non-Mendelian chromosome segregation
Genetic elements compete for transmission through meiosis, when haploid gametes are
created from a diploid parent. Selfish elements can enhance their transmission through a …
created from a diploid parent. Selfish elements can enhance their transmission through a …
[HTML][HTML] Expanded satellite repeats amplify a discrete CENP-A nucleosome assembly site on chromosomes that drive in female meiosis
A Iwata-Otsubo, JM Dawicki-McKenna, T Akera… - Current Biology, 2017 - cell.com
Female meiosis provides an opportunity for selfish genetic elements to violate Mendel's law
of segregation by increasing the chance of segregating to the egg [1]. Centromeres and …
of segregation by increasing the chance of segregating to the egg [1]. Centromeres and …
[HTML][HTML] Fertility costs of meiotic drivers
SE Zanders, RL Unckless - Current Biology, 2019 - cell.com
In sexual reproduction, opportunities are limited and the stakes are high. This inevitably
leads to conflict. One pervasive conflict occurs within genomes between alternative alleles at …
leads to conflict. One pervasive conflict occurs within genomes between alternative alleles at …
[HTML][HTML] wtf genes are prolific dual poison-antidote meiotic drivers
NL Nuckolls, MA Bravo Núñez, MT Eickbush… - Elife, 2017 - elifesciences.org
Meiotic drivers are selfish genes that bias their transmission into gametes, defying
Mendelian inheritance. Despite the significant impact of these genomic parasites on …
Mendelian inheritance. Despite the significant impact of these genomic parasites on …
Genetic villains: killer meiotic drivers
Unbiased allele transmission into progeny is a fundamental genetic concept canonized as
Mendel's Law of Segregation. Not all alleles, however, abide by the law. Killer meiotic …
Mendel's Law of Segregation. Not all alleles, however, abide by the law. Killer meiotic …
Divergence patterns of genic copy number variation in natural populations of the house mouse (Mus musculus domesticus) reveal three conserved genes with major …
Copy number variation represents a major source of genetic divergence, yet the
evolutionary dynamics of genic copy number variation in natural populations during …
evolutionary dynamics of genic copy number variation in natural populations during …