Tiny giants of gene regulation: experimental strategies for microRNA functional studies

BR Steinkraus, M Toegel… - Wiley Interdisciplinary …, 2016 - Wiley Online Library
The discovery over two decades ago of short regulatory microRNAs (miRNAs) has led to the
inception of a vast biomedical research field dedicated to understanding these powerful …

[HTML][HTML] The nematode Caenorhabditis elegans as a model organism to study metabolic effects of ω-3 polyunsaturated fatty acids in obesity

A Bouyanfif, S Jayarathne, I Koboziev… - Advances in …, 2019 - Elsevier
Obesity is a complex disease that is influenced by several factors, such as diet, physical
activity, developmental stage, age, genes, and their interactions with the environment …

Multiomics analysis revealed miRNAs as potential regulators of the immune response in Carassius auratus gills to Aeromonas hydrophila infection

J Huo, X Hu, J Bai, A Lv - Frontiers in Immunology, 2023 - frontiersin.org
The gill of fish is an important immune organ for pathogen defense, but its microRNA
(miRNA) expression and regulatory mechanism remain unclear. In this study, we report on …

MicroRNA-130b functions as a tumor suppressor by regulating RUNX3 in epithelial ovarian cancer

D Paudel, W Zhou, Y Ouyang, S Dong, Q Huang, R Giri… - Gene, 2016 - Elsevier
Aim To evaluate the clinical significance of microRNA (miR)-130b–Runt domain
transcription factor (RUNX3) axis and its effects on oncogenic phenotypes of human …

[HTML][HTML] Downregulation of microRNA-448 improves isoflurane-induced learning and memory impairment in rats

Q Wu, Q Dai, L Jiang, Y Wang… - Molecular …, 2017 - spandidos-publications.com
The present study aimed to investigate the potential role of microRNA‑448 (miR‑448) in
isoflurane-induced learning and memory impairment in rats. Sprague‑Dawley rats were …

The cell survival pathways of the primordial RNA-DNA complex remain conserved in the extant genomes and may function as proto-oncogenes

J Sinkovics - European Journal of Microbiology and Immunology, 2015 - akjournals.com
Malignantly transformed (cancer) cells of multicellular hosts, including human cells, operate
activated biochemical pathways that recognizably derived from unicellular ancestors. The …

MicroRNAs of filarial nematodes: a new frontier in host-pathogen interactions

L Tritten, TG Geary - Non-coding RNAs and Inter-kingdom Communication, 2016 - Springer
Metazoan parasites, especially nematodes, are a highly diverse group of large organisms
that typically sustain an infection for long periods of time with relatively modest pathology …

Pro‐apoptotic effects of micro‐ribonucleic acid‐365 on retinal neurons by targeting insulin‐like growth factor‐1 in diabetic rats: An in vivo and in vitro study

K Zheng, N Wang, Y Shen, Z Zhang… - Journal of Diabetes …, 2018 - Wiley Online Library
Abstract Aims/Objective The present study aimed to explore the effects of micro‐ribonucleic
acid‐365 (miR‐365) on apoptosis of retinal neurons by targeting insulin‐like growth factor‐1 …

[图书][B] A CSR-1 guided H3K36me3 signature maintains germline gene expression programs in Caenorhabditis elegans

CJ Wedeles - 2018 - search.proquest.com
Small RNA pathways related to RNA Interference (RNAi) are prevalent in species ranging
from protozoa to mammals, including humans. These pathways contribute to organismal …