Mitochondrial signalling and homeostasis: from cell biology to neurological disease

JJ Collier, M Oláhová, TG McWilliams… - Trends in …, 2023 - cell.com
Efforts to understand how mitochondrial dysfunction contributes to neurodegeneration have
primarily focussed on the role of mitochondria in neuronal energy metabolism. However …

Mitochondrial fission mediated by Drp1-Fis1 pathway and neurodegenerative diseases

W Shi, C Tan, C Liu, D Chen - Reviews in the Neurosciences, 2023 - degruyter.com
In recent years, the role of mitochondrial dynamics in neurodegenerative diseases has
becoming increasingly important. More and more evidences have shown that in pathological …

Image analysis of the mitochondrial network morphology with applications in cancer research

CH Chu, WW Tseng, CM Hsu, AC Wei - Frontiers in Physics, 2022 - frontiersin.org
Mitochondria are dynamic organelles that integrate bioenergetics, biosynthesis, and
signaling in cells and regulate redox homeostasis, apoptotic pathways, and cell proliferation …

[HTML][HTML] Unlocking the mitochondria for nanomedicine-based Treatments: Overcoming biological Barriers, improving Designs, and selecting verification techniques

C Pegoraro, I Domingo, I Conejos-Sánchez… - Advanced Drug Delivery …, 2024 - Elsevier
Enhanced targeting approaches will support the treatment of diseases associated with
dysfunctional mitochondria, which play critical roles in energy generation and cell survival …

AI-driven precision subcellular navigation with fluorescent probes

Y Zhu, Y Fang, W Huang, W Zhang, F Chen… - Journal of Materials …, 2024 - pubs.rsc.org
Precise navigation within intricate biological systems is pivotal for comprehending cellular
functions and diagnosing diseases. Fluorescent molecular probes, designed to target …

Novel DNM1L variants impair mitochondrial dynamics through divergent mechanisms

KA Nolden, JM Egner, JJ Collier… - Life Science …, 2022 - life-science-alliance.org
Imbalances in mitochondrial and peroxisomal dynamics are associated with a spectrum of
human neurological disorders. Mitochondrial and peroxisomal fission both involve dynamin …

Mitochondrial nanoprobe for precise cellular and drug analysis via graph Neural network

H He, G Qin, M Xue, Z Feng, J Mao, W Tao… - Chemical Engineering …, 2024 - Elsevier
Mitochondrial morphology is crucial for cell identification and drug toxicity evaluation, yet it is
challenged by mitochondrial complexities and limitations in imaging technologies. We …