Selenium is an essential micronutrient with important functions in human health and
relevance to several pathophysiological conditions. The biological effects of selenium are …

Selenium is a vital trace element present as selenocysteine (Sec) in proteins that are, thus,
known as selenoproteins. Humans have 25 selenoproteins, most of which are functionally …

The human selenoprotein family contains 25 members that share the common feature of
containing the amino acid, selenocysteine (Sec). Seven selenoproteins are localized to the …

The brain has a very high oxygen consumption rate and is particularly sensitive to oxidative
stress. It is also the last organ to suffer from a loss of selenium (Se) in case of deficiency. Se …

Glutathione peroxidases (GPxs) are enzymes working with either selenium or sulfur
catalysis. They adopted diverse functions ranging from detoxification of H 2 O 2 to redox …

Abstract Selenocysteine (Sec), the 21st genetically encoded amino acid, is structurally
similar to cysteine (Cys) but with a sulfur to selenium replacement. This small change …

Chronic metabolic stress leads to cellular dysfunction, characterized by excessive reactive
oxygen species, endoplasmic reticulum (ER) stress and inflammation, which has been …

Background The impact of selenium status on the long-term health of people with type 2
diabetes (T2D) remains unclear. Objectives To prospectively examine the association of …

Studies of selenium (Se) status indicate that Se is necessary for fertility but how precisely is
not known. We aimed to show that Se was important in bovine female reproductive function …

Highlights•Selenocysteine endows proteins with novel redox properties.•New recombinant
and chemical methods are facilitating selenoprotein production.•Many natural …