[HTML][HTML] New insights into the molecular characteristics of pulmonary carcinoids and large cell neuroendocrine carcinomas, and the impact on their clinical …

JL Derks, N Leblay, S Lantuejoul… - Journal of Thoracic …, 2018 - Elsevier
Carcinoids and large cell neuroendocrine carcinomas (LCNECs) are rare neuroendocrine
lung tumors. Here we provide an overview of the most updated data on the molecular …

Patient-derived lung cancer organoids as in vitro cancer models for therapeutic screening

M Kim, H Mun, CO Sung, EJ Cho, HJ Jeon… - Nature …, 2019 - nature.com
Lung cancer shows substantial genetic and phenotypic heterogeneity across individuals,
driving a need for personalised medicine. Here, we report lung cancer organoids and …

Large cell neuroendocrine carcinoma of the lung: current understanding and challenges

E Andrini, PV Marchese, D De Biase… - Journal of Clinical …, 2022 - mdpi.com
Large cell neuroendocrine carcinoma of the lung (LCNEC) is a rare and highly aggressive
type of lung cancer, with a complex biology that shares similarities with both small-cell lung …

Integrative genomic profiling of large-cell neuroendocrine carcinomas reveals distinct subtypes of high-grade neuroendocrine lung tumors

J George, V Walter, M Peifer, LB Alexandrov… - Nature …, 2018 - nature.com
Pulmonary large-cell neuroendocrine carcinomas (LCNECs) have similarities with other
lung cancers, but their precise relationship has remained unclear. Here we perform a …

The prognostic and therapeutic role of genomic subtyping by sequencing tumor or cell-free DNA in pulmonary large-cell neuroendocrine carcinoma

M Zhuo, Y Guan, X Yang, L Hong, Y Wang, Z Li… - Clinical Cancer …, 2020 - AACR
Purpose: The optimal systemic treatment for pulmonary large-cell neuroendocrine
carcinoma (LCNEC) is still under debate. Previous studies showed that LCNEC with …

Large cell neuroendocrine carcinoma of the lung: clinico-pathologic features, treatment, and outcomes

J Naidoo, ML Santos-Zabala, T Iyriboz, KM Woo… - Clinical lung cancer, 2016 - Elsevier
Background Large cell neuroendocrine carcinoma (LCNEC) accounts for approximately 3%
of lung cancers. Pathologic classification and optimal therapies are debated. We report the …

Chemotherapy for pulmonary large cell neuroendocrine carcinomas: does the regimen matter?

JL Derks, RJ Van Suylen, E Thunnissen… - European …, 2017 - Eur Respiratory Soc
Pulmonary large cell neuroendocrine carcinoma (LCNEC) is rare. Chemotherapy for
metastatic LCNEC ranges from small cell lung carcinoma (SCLC) regimens to nonsmall cell …

Large cell neuro-endocrine carcinoma of the lung: current treatment options and potential future opportunities

MG Ferrara, A Stefani, M Simbolo, S Pilotto… - Frontiers in …, 2021 - frontiersin.org
Large-cell neuroendocrine carcinomas of the lung (LCNECs) are rare tumors representing 1–
3% of all primary lung cancers. Patients with LCNEC are predominantly male, older, and …

Large-cell neuroendocrine carcinoma of the lung: a population-based study

CJ Kinslow, MS May, A Saqi, CA Shu, KR Chaudhary… - Clinical lung cancer, 2020 - Elsevier
Introduction Large-cell neuroendocrine carcinoma (LCNEC) accounts for approximately 3%
of lung malignancies. There are limited data on the epidemiology and best treatment …

High-grade neuroendocrine carcinoma of the lung with carcinoid morphology: a study of 12 cases

AM Quinn, A Chaturvedi, D Nonaka - The American journal of …, 2017 - journals.lww.com
Twelve lung neuroendocrine tumors with morphologic features of carcinoid tumors but with
mitotic count> 10/2 mm 2 are reported. There were 7 males and 5 females, with age ranging …