Ion channels of the Transient Receptor Potential (TRP) family mediate the influx of
monovalent and/or divalent cations into cells in response to a host of chemical or physical …

G-protein coupled receptors (GPCRs) govern the physiological response to stimuli by
modulating the activity of downstream effectors, including ion channels. TRPM3 is an ion …

Acute pain represents a crucial alarm signal to protect us from injury. Whereas the
nociceptive neurons that convey pain signals were described more than a century ago, the …

The perception of nociceptive signals, which are translated into pain, plays a fundamental
role in the survival of organisms. Because pain is linked to a negative sensation, animals …

Chronic pain treatment remains a sore challenge, and in our aging society, the number of
patients reporting inadequate pain relief continues to grow. Current treatment options all …

When we edited in 2007 the first issue on transient receptor potential channel in the
Handbook of Experimental Pharmacology, we were all very excited by the progress in this …

In β cells, stimulation by metabolic, hormonal, neuronal, and pharmacological factors is
coupled to secretion of insulin through different intracellular signaling pathways. Our …

The transient receptor potential melastatin (TRPM) subfamily belongs to the TRP cation
channels family. Since the first cloning of TRPM1 in 1989, tremendous progress has been …

Transient receptor potential (TRP) cation channel subfamily M member 3 (TRPM3), a
member of the TRP channel superfamily, was recently identified as a nociceptor channel in …

Transient receptor potential (TRP) channels form a diverse family of cation channels
comprising 28 members in mammals. Although some TRP proteins can only be found on …