The Wistar Audiogenic Rat (WAR) strain and its contributions to epileptology and related comorbidities: history and perspectives

N Garcia-Cairasco, EHL Umeoka, JAC de Oliveira - Epilepsy & Behavior, 2017 - Elsevier
In the context of modeling epilepsy and neuropsychiatric comorbidities, we review the Wistar
Audiogenic Rat (WAR), first introduced to the neuroscience international community more …

Genetics of reflex seizures and epilepsies in humans and animals

D Italiano, P Striano, E Russo, A Leo, E Spina, F Zara… - Epilepsy research, 2016 - Elsevier
Introduction Reflex seizures are epileptic events triggered by specific motor, sensory or
cognitive stimulation. This comprehensive narrative review focuses on the role of genetic …

[HTML][HTML] Genetically epilepsy-prone rats display anxiety-like behaviors and neuropsychiatric comorbidities of epilepsy

BL Aguilar, L Malkova, P N'Gouemo… - Frontiers in …, 2018 - frontiersin.org
Epilepsy is associated with a variety of neuropsychiatric comorbidities, including both
anxiety and depression. Despite high occurrences of depression and anxiety seen in human …

Perinatal exposure to FireMaster® 550 (FM550), brominated or organophosphate flame retardants produces sex and compound specific effects on adult Wistar rat …

SK Witchey, L Al Samara, BM Horman… - Hormones and …, 2020 - Elsevier
Abstract Firemaster 550 (FM550) is a flame retardant (FR) mixture that has become one of
the most commonly used FRs in household items such as foam-based furniture and baby …

[HTML][HTML] Increased TRPV1 channels and FosB protein expression are associated with chronic epileptic seizures and Anxiogenic-like behaviors in a preclinical model …

W Lazarini-Lopes, GK Silva-Cardoso… - Biomedicines, 2022 - mdpi.com
Epilepsies are neurological disorders characterized by chronic seizures and their related
neuropsychiatric comorbidities, such as anxiety. The Transient Receptor Potential Vanilloid …

[HTML][HTML] Audiogenic Seizures and Social Deficits: No Aggravation Found in Krushinsky–Molodkina Rats

A Rebik, N Broshevitskaya, S Kuzhuget, P Aleksandrov… - Biomedicines, 2023 - mdpi.com
Epilepsy or epileptic syndromes affect more than 70 million people, often comorbid with
autism spectrum disorders (ASD). Seizures are concerned as a factor for social regression in …

[HTML][HTML] On temporal scale-free non-periodic stimulation and its mechanisms as an infinite improbability drive of the brain's functional connectogram

VR Cota, SAV Cançado, MFD Moraes - Frontiers in Neuroinformatics, 2023 - frontiersin.org
Rationalized development of electrical stimulation (ES) therapy is of paramount importance.
Not only it will foster new techniques and technologies with increased levels of safety …

[HTML][HTML] Cannabinoid receptor type 1 (CB1R) expression in limbic brain structures after acute and chronic seizures in a genetic model of epilepsy

W Lazarini-Lopes, RMP da Silva-Júnior… - Frontiers in Behavioral …, 2020 - frontiersin.org
The endocannabinoid system (ECS) is related to several physiological processes,
associated to the modulation of brain excitability, with impact in the expression of …

Efficacy of Cicuta virosa medicinal preparations against pentylenetetrazole-induced seizures

P Mishra, JK Sinha, SK Rajput - Epilepsy & Behavior, 2021 - Elsevier
Epileptic seizures are characterized by imbalanced inhibition-excitation cycle that triggers
biochemical alterations responsible for jeopardized neuronal integrity. Conventional …

[HTML][HTML] Epilepsy as a dynamical system, a most needed paradigm shift in epileptology

MFD Moraes, D de Castro Medeiros, FAG Mourao… - Epilepsy & Behavior, 2021 - Elsevier
The idea of the epileptic brain being highly excitable and facilitated to synchronic activity has
guided pharmacological treatment since the early twentieth century. Although tackling …