Patients with severe combined immunodeficiency (SCID) disease have classically been
divided into those with residual B cells (TÀB+ phenotype) and those whose defects produce …

Adenosine deaminase (ADA)-deficient Severe Combined Immunodeficiency (ADA-deficient
SCID) is characterized by impaired lymphocyte development and function resulting from the …

The optimal approach for stem cell transplantation in children with immunodeficiency has yet
to be determined. Conditioning therapy is necessary for reliable engraftment and full …

We studied T-cell reconstitution in 31 primary T-cell–immunodeficient patients who had
undergone hematopoietic stem-cell transplantation (HSCT) over 10 years previously. In 19 …

A distinct form of autosomal recessive T− B− severe combined immunodeficiency disease
occurs with a high frequency among Athabascan-speaking Native Americans (SCIDA) …

For infants with SCID, the ideal conditioning regimen before allogeneic HCT would omit
cytotoxic chemotherapy to minimize short‐and long‐term complications. We performed a …

Haemopoietic stem cell transplants (HSCT) cure increasing numbers of primary
immunodeficiencies (PID): residual recipient T-cell function increases risk of incomplete or …

SCID is a fatal syndrome caused by mutations in at least 13 different genes. It is
characterized by the absence of T cells. Immune reconstitution can be achieved through …

Background: SCID can be cured by BMT. Depletion of mature T cells from BM has enabled
HLA non-identical stem-cell transplantation. We report the outcome of 30 patients treated …

Bone marrow transplantation to treat autosomal recessive severe combined
immunodeficiency was undertaken in a one-month-old girl. The donor was the patient's HLA …