It is important that the medical profession play a significant role in critically evaluating the
use of diagnostic procedures and therapies as they are introduced and tested in the …

Heart failure (HF) is a major and growing public health problem in the United States.
Approximately 5 million patients in this country have HF, and over 550 000 patients are …

Context The Digitalis Investigation Group (DIG) trial reported that digoxin provided no overall
mortality benefit and only a modest reduction in hospitalizations among patients with heart …

Aims Digoxin is frequently used for rate control of atrial fibrillation (AF). It has, however, been
associated with increased mortality. It remains unclear whether digoxin itself is responsible …

Heart failure (HF) is a syndrome characterized by high mortality, frequent hospitalization,
reduced quality of life, and a complex therapeutic regimen. Knowledge about HF is …

Aims To determine the effects of digoxin on all-cause mortality and heart failure (HF)
hospitalizations, regardless of ejection fraction, accounting for serum digoxin concentration …

The sodium pump, Na+/K+-ATPase, could be an important target for the development of anti-
cancer drugs as it serves as a versatile signal transducer, it is a key player in cell adhesion …

(1) Baroreceptor function: In lowoutput HF models, there is attenuation of carotid sinus
baroreceptor discharge sensitivity. Administration of digoxin produces improvement in …

Objectives: The purpose of this study was to investigate the relationship of serum digoxin
concentration (SDC) and outcomes in women with heart failure (HF). Background …

Digitalis is the oldest compound in cardiovascular medicine that continues to be used in
contemporary clinical practice. 1 Evidence supporting the beneficial effects of digoxin on …