Iron is a transition metal and essential constituent of almost all living cells and organisms. As
component of various metalloproteins it is involved in critical biochemical processes such as …

Anemia is very common in patients with inflammatory disorders. Its prevalence is associated
with severity of the underlying disease, and it negatively affects quality of life and cardio …

Production of minute concentrations of superoxide (O 2 radical dot−) and nitrogen monoxide
(nitric oxide, NO radical dot) plays important roles in several aspects of cellular signaling …

Iron regulatory proteins 1 and 2 (IRP1 and IRP2) post-transcriptionally control the
expression of several mRNAs encoding proteins of iron, oxygen and energy metabolism …

The iron storage protein, ferritin, plays a key role in iron metabolism. Its ability to sequester
the element gives ferritin the dual functions of iron detoxification and iron reserve. The …

BACKGROUND: Iron is utilized by several proteins as cofactor for major biological
processes. However, iron may also harm cells by catalyzing the generation of free radicals …

This review focuses on the role of oxidative processes in atherosclerosis and its resultant
cardiovascular events. There is now a consensus that atherosclerosis represents a state of …

Reactive Oxygen Species (ROS) are produced during normal cellular function. ROS include
hydroxyl radicals, superoxide anion, hydrogen peroxide and nitric oxide. They are very …

Increasingly, perturbations in cellular iron and ferritin are emerging as an important element
in the pathogenesis of disease. These changes in ferritin are important not only in the classic …

Iron is vital for almost all living organisms by participating in a wide variety of metabolic
processes, including oxygen transport, DNA synthesis, and electron transport. However, iron …