The National Institute of Mental Health (NIMH) proposed the Research Domain Criteria
(RDoC) initiative as an alternate way to organize research of mental illnesses, by looking at …

Although irritability is among the most common reasons that children and adolescents are
brought for psychiatric care, there are few effective treatments. Developmentally sensitive …

Shortcomings of approaches to classifying psychopathology based on expert consensus
have given rise to contemporary efforts to classify psychopathology quantitatively. In this …

Objective The aim of this study is to perform the first meta-meta-analysis on the effectiveness
of parent-based interventions for children with externalizing behavior problems. Even …

Objective Irritability is a transdiagnostic indicator of child and adolescent internalizing and
externalizing problems that is measurable from early life. The objective of this systematic …

The arrival of the Journal's 175th anniversary occurs at a time of recent advances in
research, providing an ideal opportunity to present a neurodevelopmental roadmap for …

Irritability is a common and impairing clinical presentation in children and adolescents.
Despite its significant public health impact, irritability remains an elusive construct. Chronic …

Irritability, defined as an increased propensity to exhibit increased anger relative to one's
peers, is a common clinical problem in youth. Irritability can be conceptualized as aberrant …

Attention deficit hyperactivity disorder (ADHD) is emblematic of unresolved heterogeneity in
psychiatric disorders—the variation in biological, clinical, and psychological correlates that …

Mental disorders are the predominant chronic diseases of youth, with substantial life span
morbidity and mortality. A wealth of evidence demonstrates that the neurodevelopmental …