Nonamorphism in flufenamic acid and a new record for a polymorphic compound with solved structures

V López-Mejías, JW Kampf… - Journal of the American …, 2012 - ACS Publications
The unprecedented polymorphism of the non-steroidal anti-inflammatory drug (NSAID)
flufenamic acid (FFA) is described here. Nine polymorphs were accessed through the use of …

Solubility advantage of tenoxicam phenolic cocrystals compared to salts

G Bolla, P Sanphui, A Nangia - Crystal growth & design, 2013 - ACS Publications
Tenoxicam (TNX) belongs to the oxicam family of drugs popularly known as nonsteroidal
anti-inflammatory drugs (NSAIDs). Its therapeutic action as a drug is limited by poor aqueous …

High-pressure polymorphism in hydrogen-bonded crystals: a concise review

T Yan, D Xi, Q Fang, Y Zhang, J Wang, X Wang - Crystals, 2022 - mdpi.com
High-pressure polymorphism is a developing interdisciplinary field. Pressure up to 20 GPa is
a powerful thermodynamic parameter for the study and fabrication of hydrogen-bonded …

A to Z of polymorphs related by proton transfer

A Woods-Ryan, CL Doherty, AJ Cruz-Cabeza - CrystEngComm, 2023 - pubs.rsc.org
The occurrence of tautomeric polymorphism in the Cambridge Structural Database (CSD)
was established to be very rare in a previous study by AJ Cruz-Cabeza and CR Groom …

Accurate hydrogen positions in organic crystals: Assessing a quantum-chemical aide

VL Deringer, V Hoepfner… - Crystal growth & design, 2012 - ACS Publications
Organic molecules crystallize in manifold structures. The last few decades have seen the
rise of high-resolution X-ray diffraction techniques that make the structures of even the most …

A solubility comparison of neutral and zwitterionic polymorphs

SS Kumar, A Nangia - Crystal growth & design, 2014 - ACS Publications
Several amphoteric model compounds and drugs, such as isomers of aminobenzoic acids
(ortho, meta, and para), N-aryl-2-amino-nicotinic acids (three isomers), amino-salicylic acids …

Lornoxicam salts: crystal structures, conformations, and solubility

K Suresh, A Nangia - Crystal growth & design, 2014 - ACS Publications
Lornoxicam (LXM), a nonsteroidal anti-inflammatory drug (NSAID), is an amphiprotic
molecule that exists as a zwitterion in the solid state. The formation of two strong …

Crystal engineering of a zwitterionic drug to neutral cocrystals: a general solution for floxacins

A Gunnam, K Suresh, R Ganduri… - Chemical …, 2016 - pubs.rsc.org
The transformation of zwitterionic Sparfloxacin (SPX) to the neutral form is achieved by
cocrystallization. Neutral forms of drugs are important for higher membrane permeability …

Selective preparation of elusive and alternative single component polymorphic solid forms through multi-component crystallisation routes

LH Thomas, C Wales, CC Wilson - Chemical Communications, 2016 - pubs.rsc.org
A transferable, simple, method for producing previously elusive and novel polymorphic
forms of important active pharmaceutical ingredients (APIs; paracetamol (acetaminophen) …

Crystal structures of pyridine sulfonamides and sulfonic acids

K Akiri, S Cherukuvada, S Rana… - Crystal growth & …, 2012 - ACS Publications
Despite the widespread occurrence of pyridinesulfonic acid and pyridinesulfonamide
functional groups in drugs and pharmaceuticals, and their use as ligands in metal–organic …