Multidrug resistance (MDR) in cancer: mechanisms, reversal using modulators of MDR and the role of MDR modulators in influencing the pharmacokinetics of …
R Krishna, LD Mayer - European journal of pharmaceutical sciences, 2000 - Elsevier
In recent years, there has been an increased understanding of P-glycoprotein (P-GP)-
mediated pharmacokinetic interactions. In addition, its role in modifying the bioavailability of …
mediated pharmacokinetic interactions. In addition, its role in modifying the bioavailability of …
The ATP-dependent glutathione S-conjugate export pump
T Ishikawa - Trends in biochemical sciences, 1992 - Elsevier
The ATP-dependent glutathione S-conjugate export pump (GS-X pump) plays a
physiologically important role as a member of the 'phase III'system in xenobiotic metabolism …
physiologically important role as a member of the 'phase III'system in xenobiotic metabolism …
Drug resistance and ATP-dependent conjugate transport mediated by the apical multidrug resistance protein, MRP2, permanently expressed in human and canine …
The multidrug resistance protein MRP1 functions as an ATP-dependent conjugate export
pump and confers multidrug resistance. We cloned MRP2 (symbol ABCC2), a MRP family …
pump and confers multidrug resistance. We cloned MRP2 (symbol ABCC2), a MRP family …
The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates.
I Leier, G Jedlitschky, U Buchholz, SPC Cole… - Journal of Biological …, 1994 - Elsevier
The multidrug resistance-associated protein (MRP) is the product of an ATP-binding
cassette transporter gene overexpressed in some tumor cells resistant to antineoplastic …
cassette transporter gene overexpressed in some tumor cells resistant to antineoplastic …
[HTML][HTML] Conjugate export pumps of the multidrug resistance protein (MRP) family: localization, substrate specificity, and MRP2-mediated drug resistance
The membrane proteins mediating the ATP-dependent transport of lipophilic substances
conjugated to glutathione, glucuronate, or sulfate have been identified as members of the …
conjugated to glutathione, glucuronate, or sulfate have been identified as members of the …
[PDF][PDF] A mutation in the human canalicular multispecific organic anion transporter gene causes the Dubin‐Johnson syndrome
Abstract The human Dubin‐Johnson syndrome (DJS) is a rare autosomal recessive liver
disorder characterized by chronic conjugated hyperbilirubinemia. Patients have impaired …
disorder characterized by chronic conjugated hyperbilirubinemia. Patients have impaired …
[HTML][HTML] The apical conjugate efflux pump ABCC2 (MRP2)
ABCC2 is a member of the multidrug resistance protein subfamily localized exclusively to
the apical membrane domain of polarized cells, such as hepatocytes, renal proximal tubule …
the apical membrane domain of polarized cells, such as hepatocytes, renal proximal tubule …
Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene
CC Paulusma, PJ Bosma, GJR Zaman, CTM Bakker… - Science, 1996 - science.org
The human Dubin-Johnson syndrome and its animal model, the TR− rat, are characterized
by a chronic conjugated hyperbilirubinemia. TR− rats are defective in the canalicular …
by a chronic conjugated hyperbilirubinemia. TR− rats are defective in the canalicular …
[HTML][HTML] The leukotriene C4 transporter MRP1 regulates CCL19 (MIP-3β, ELC)–dependent mobilization of dendritic cells to lymph nodes
DF Robbiani, RA Finch, D Jäger, WA Muller… - Cell, 2000 - cell.com
Adaptive immune responses begin after antigen-bearing dendritic cells (DCs) traffic from
peripheral tissues to lymph nodes. Here, we show that DC migration from skin to lymph …
peripheral tissues to lymph nodes. Here, we show that DC migration from skin to lymph …
[HTML][HTML] Multidrug Resistance Protein (MRP)-mediated Transport of Leukotriene C4 and Chemotherapeutic Agents in Membrane Vesicles: Demonstration of …
The 190-kDa multidrug resistance protein (MRP) has recently been associated with the
transport of cysteinyl leukotrienes and several glutathione (GSH) S-conjugates. In the …
transport of cysteinyl leukotrienes and several glutathione (GSH) S-conjugates. In the …