The UFM1 system: Working principles, cellular functions, and pathophysiology

M Komatsu, T Inada, NN Noda - Molecular Cell, 2024 - cell.com
Summary Ubiquitin-fold modifier 1 (UFM1) is a ubiquitin-like protein covalently conjugated
with intracellular proteins through UFMylation, a process similar to ubiquitylation. Growing …

Recent insights into the biomarkers, molecular targets and mechanisms of non-alcoholic steatohepatitis-driven hepatocarcinogenesis

A Kakehashi, S Suzuki, H Wanibuchi - Cancers, 2023 - mdpi.com
Simple Summary This review is focused on the research recently published in the field of
non-alcoholic fatty liver disease (NAFLD) or metabolic dysfunction-associated steatotic liver …

The post-translational role of UFMylation in physiology and disease

X Wang, X Xu, Z Wang - Cells, 2023 - mdpi.com
Ubiquitin-fold modifier 1 (UFM1) is a newly identified ubiquitin-like protein that has been
conserved during the evolution of multicellular organisms. In a similar manner to ubiquitin …

[HTML][HTML] Panaxatriol exerts anti-senescence effects and alleviates osteoarthritis and cartilage repair fibrosis by targeting UFL1

B Kuang, N Geng, M Yi, Q Zeng, M Fan, M Xian… - Journal of Advanced …, 2024 - Elsevier
Introduction Osteoarthritis (OA), the most common degenerative joint disease, can
eventually lead to disability. However, no safe or effective intervention is currently available …

Role of UFMylation in tumorigenesis and cancer immunotherapy

L Ding, X Jiang, T Li, S Wang - Frontiers in Immunology, 2024 - frontiersin.org
Protein post-translational modifications (PTMs) represent a crucial aspect of cellular
regulation, occurring after protein synthesis from mRNA. These modifications, which include …

The emerging roles of UFMylation in the modulation of immune responses

Z Liang, R Ning, Z Wang, X Kong, Y Yan… - Clinical and …, 2024 - Wiley Online Library
Post‐translational modification is a rite of passage for cellular functional proteins and
ultimately regulate almost all aspects of life. Ubiquitin‐fold modifier 1 (UFM1) system …

Identification of FGG as a Biomarker in Early Gastric Cancer via Tissue Proteomics and Clinical Verification

W Chen, Q Ye, B Zhang, Z Ma, H Tu - Journal of Proteome …, 2024 - ACS Publications
Early and accurate diagnosis of gastric cancer (GC) is essential for reducing mortality and
improving patient well-being. However, methods for the early diagnosis of GC are still …

DysUFMylation of SREBP1 promotes the progression of hepatocellular carcinoma by reprogramming lipid metabolism

Y Yi, X Gao, Z Han, Z Wang, G Sun, H Xiao, D Zhang… - 2024 - researchsquare.com
SREBP1 (sterol regulatory element-binding protein 1), a master regulator involved in
lipogenesis, is highly expressed in tumors. SREBP1 is regulated by posttranslational …

Understanding the role UFMylation plays in prostate cancer

DS Gill - 2024 - eprints.qut.edu.au
The aim of this research was to identify proteins that are modified by a post-translational
process called UFMylation in prostate cancer. Despite being discovered two decades ago …