Thrombotic thrombocytopenic purpura (TTP) is a rare thrombotic microangiopathy
characterized by microangiopathic hemolytic anemia, severe thrombocytopenia, and …

Thrombotic thrombocytopenic purpura (TTP; also known as Moschcowitz disease) is
characterized by the concomitant occurrence of often severe thrombocytopenia …

Pathogenesis of thrombotic thrombocytopenic purpura (TTP) was a mystery for over half a
century until the discovery of ADAMTS13. ADAMTS13 is primarily synthesized in the liver …

Haematological manifestations in systemic lupus erythematosus (SLE) are frequently
observed. They are diverse and range from mild to severe. Therefore, different treatment …

Introduction: Thrombotic thrombocytopenic purpura (TTP) is a rare and life-threatening
thrombotic microangiopathy characterized by microangiopathic hemolytic anemia …

At least 13 different disease entities affecting the central nervous system, peripheral nervous
system and connective tissue of the skin or kidneys are associated with immunoglobulin G4 …

Summary ADAMTS‐13, a plasma reprolysin‐like metalloprotease, cleaves von W illebrand
factor (VWF). Severe deficiency of plasma ADAMTS‐13 activity results in thrombotic …

Background Acquired thrombotic thrombocytopenic purpura (TTP) is an autoimmune
disease in which anti-ADAMTS13 autoantibodies cause severe enzyme deficiency …

Essentials• Conformational changes in ADAMTS‐13 are part of its mode‐of‐action.• The
murine anti‐ADAMTS‐13 antibody 1C4 discriminates between folded and open ADAMTS …

Thrombotic thrombocytopenic purpura (TTP) is primarily caused by immunoglobulin G (IgG)
autoantibodies against A Disintegrin And Metalloprotease with ThromboSpondin type 1 …