Comprehensive metabolite profiling of Berdav propolis using LC-MS/MS: Determination of antioxidant, anticholinergic, antiglaucoma, and antidiabetic effects

H Karagecili, MA Yılmaz, A Ertürk, H Kiziltas, L Güven… - Molecules, 2023 - mdpi.com
Propolis is a complex natural compound that honeybees obtain from plants and contributes
to hive safety. It is rich in phenolic and flavonoid compounds, which contain antioxidant …

Antioxidant, antidiabetic, anticholinergic, and antiglaucoma effects of magnofluorine

L Durmaz, H Kiziltas, L Guven, H Karagecili, S Alwasel… - Molecules, 2022 - mdpi.com
Magnofluorine, a secondary metabolite commonly found in various plants, has
pharmacological potential; however, its antioxidant and enzyme inhibition effects have not …

Novel Quinazolinone Derivatives: Potential Synthetic Analogs for the Treatment of Glaucoma, Alzheimer's Disease and Diabetes Mellitus

FS Tokalı, P Taslimi, B Tuzun, A Karakuş… - Chemistry & …, 2023 - Wiley Online Library
Quinazolinones, which represent an important part of nitrogen‐containing six‐membered
heterocyclic compounds, are frequently used in drug design due to their wide biological …

Synthesis and Evaluation of Quinazolin‐4(3H)‐one Derivatives as Multitarget Metabolic Enzyme Inhibitors: A Biochemistry‐Oriented Drug Design

FS Tokalı, P Taslimi, M Sadeghi, H Şenol - ChemistrySelect, 2023 - Wiley Online Library
In this study, imines bearing quinazolin‐4 (3H)‐one were synthesized and their inhibitory
properties were investigated against some metabolic enzymes including …

Design, synthesis, characterization, crystal structure, in silico studies, and inhibitory properties of the PEPPSI type Pd (II) NHC complexes bearing chloro/fluorobenzyl …

Y Gök, P Taslimi, B Şen, S Bal, A Aktaş, M Aygün… - Bioorganic …, 2023 - Elsevier
This work contains synthesis, characterization, crystal structure, and biological activity of a
new series of the PEPPSI type Pd (II) NHC complexes [(NHC) Pd (II)(3-Cl-py)]. NMR, FTIR …

Schiff base compounds constructed from pyrazole–acetamide: Synthesis, spectroscopic characterization, crystal structure, DFT, molecular docking and antioxidant …

G Al Ati, K Chkirate, O El-Guourrami… - Journal of Molecular …, 2024 - Elsevier
Two new Schiff base compounds, namely N-(2-((4-(dimethylamino) benzylidene) amino)
phenyl)-2-(5-methyl-1H-pyrazol-3-yl) acetamide (DBPA) and N-(2-((4-methoxybenzylidene) …

Synthesis, characterization, bioactivity impacts of new anthranilic acid hydrazones containing aryl sulfonate moiety as fenamate isosteres

FS Tokalı, P Taslimi, N Sadeghian… - …, 2023 - Wiley Online Library
In this study, it was planned to synthesize new members of fenamate isosteres and
investigate its effect on some metabolic enzymes such as Acetylcholinesterase …

Synthesis and biological activity of functionally substituted pyrimidine and pyran derivatives on the basis of isatylidene malononitriles

F Naghiyev, I Mamedov, R Askerov, P Taslimi… - …, 2022 - Wiley Online Library
In this study, it was shown that pyrimidine and imidazopyridine derivatives were obtained
from the multicomponent reaction of isatylidene malononitriles with malononitrile and …

Novel Benzoic Acid Derivatives Bearing Quinazolin‐4(3H)‐one Ring: Synthesis, Characterization, and Inhibition Effects on α‐Glucosidase and α‐Amylase

F Sinan Tokalı - ChemistrySelect, 2022 - Wiley Online Library
In this study, new benzoic acid derivatives of the quinazolinone ring, which is one of the
biologically active members of nitrogen‐containing heterocyclic compounds, were …

Phosphine chalcogenides and their derivatives from red phosphorus and functionalized pyridines, imidazoles, pyrazoles and their antimicrobial and cytostatic activity

S Malysheva, V Kuimov, L Belovezhets… - Bioorganic …, 2023 - Elsevier
Tertiary phosphine oxides, phosphine sulfides, and phosphine selenides containing
pyridine, imidazole, and pyrazole groups have been synthesized via the reaction of …