The cellular elements lining the internal surface and inside the cyst The environment around
the endometriotic cyst† Conclusions and future research background: Clinical data suggest …

Endometriosis is currently defined as presence of endometrial epithelial and stromal cells at
ectopic sites. This simple and straightforward definition has served us well since its original …

Smooth muscle metaplasia (SMM) and fibrotic tissues are frequently seen in endometriotic
lesions, yet the mechanisms underlying their formation are poorly understood. In this study …

The oxytocin receptor (OXTR), encoded by the OXTR gene, is responsible for the signal
transduction after binding its ligand, oxytocin. Although this signaling is primarily involved in …

BACKGROUND Fibrosis is an important pathological feature of endometriotic lesions of all
subtypes. Fibrosis is present in and around endometriotic lesions, and a central role in its …

We have recently shown that platelets play important roles in development of endometriosis
and proposed that endometriotic lesions are essentially wounds that undergo repeated …

Endometriosis is a common and painful condition affecting women of reproductive age.
While the underlying pathophysiology is still largely unknown, much advancement has been …

OBJECTIVE: To evaluate uterine contractility, oxytocin receptor (OTR) expression in
myometrial smooth muscle cells (MSMCs) derived from uterine tissues from women with and …

Oxytocin was once understood solely as a neuropeptide with a central role in social
bonding, reproduction, parturition, lactation and appetite regulation. Recent evidence …

Endometriosis-related fibrosis represents a complex phenomenon with underlying
mechanisms yet to be clarified. Fibrosis is consistently present in all disease forms and …