Mass spectrometry for structural elucidation and sequencing of carbohydrates

J Wang, J Zhao, S Nie, M Xie, S Li - TrAC Trends in Analytical Chemistry, 2021 - Elsevier
Carbohydrates are the most abundant organic compounds in nature, widely distributed in
animals, plants and microorganisms. In order to understanding their structure properties, the …

Analysis of carbohydrates and glycoconjugates by matrix‐assisted laser desorption/ionization mass spectrometry: An update for 2017–2018

DJ Harvey - Mass Spectrometry Reviews, 2023 - Wiley Online Library
This review is the tenth update of the original article published in 1999 on the application of
matrix‐assisted laser desorption/ionization mass spectrometry (MALDI) mass spectrometry …

Toward automatic and comprehensive glycan characterization by online PGC-LC-EED MS/MS

J Wei, Y Tang, Y Bai, J Zaia, CE Costello… - Analytical …, 2019 - ACS Publications
Despite the recent advances in mass spectrometry (MS)-based methods for glycan structural
analysis, characterization of glycomes remains a significant analytical challenge, in part due …

Identification of the High Mannose N-Glycan Isomers Undescribed by Conventional Multicellular Eukaryotic Biosynthetic Pathways

CY Liew, HS Luo, TY Yang, AT Hung… - Analytical …, 2023 - ACS Publications
N-linked glycosylation is one of the most important post-translational modifications of
proteins. Current knowledge of multicellular eukaryote N-glycan biosynthesis suggests high …

Structural identification of N-glycan isomers using logically derived sequence tandem mass spectrometry

CY Liew, CC Yen, JL Chen, ST Tsai, S Pawar… - Communications …, 2021 - nature.com
N-linked glycosylation is one of the most important protein post-translational modifications.
Despite the importance of N-glycans, the structural determination of N-glycan isomers …

Unusual free oligosaccharides in human bovine and caprine milk

WC Weng, HE Liao, SP Huang, ST Tsai, HC Hsu… - Scientific Reports, 2022 - nature.com
Free oligosaccharides are abundant macronutrients in milk and involved in prebiotic
functions and antiadhesive binding of viruses and pathogenic bacteria to colonocytes …

How general is anomeric retention during collision-induced dissociation of glycans?

RP Pellegrinelli, L Yue, E Carrascosa… - Journal of the …, 2020 - ACS Publications
Despite the essential role that glycans play in many biological processes, their isomeric
complexity makes their structural determination particularly challenging. Tandem mass …

Simple method for de novo structural determination of underivatised glucose oligosaccharides

HC Hsu, CY Liew, SP Huang, ST Tsai, CK Ni - Scientific Reports, 2018 - nature.com
Carbohydrates have various functions in biological systems. However, the structural
analysis of carbohydrates remains challenging. Most of the commonly used methods involve …

Collision-induced dissociation of sodiated glucose, galactose, and mannose, and the identification of anomeric configurations

HT Huynh, HT Phan, PJ Hsu, JL Chen… - Physical Chemistry …, 2018 - pubs.rsc.org
Collision-induced dissociation of sodiated α-glucose, β-glucose, α-galactose, β-galactose, α-
mannose, and β-mannose was studied using electronic structure calculations and …

Automatic full glycan structural determination through logically derived sequence tandem mass spectrometry

ST Tsai, CY Liew, C Hsu, SP Huang, WC Weng… - …, 2019 - Wiley Online Library
Glycans have diverse functions and play vital roles in many biological systems, such as
influenza, vaccines, and cancer biomarkers. However, full structural identification of glycans …