Weight loss associated with sodium‐glucose cotransporter‐2 inhibition: a review of evidence and underlying mechanisms

PC Lee, S Ganguly, SY Goh - Obesity Reviews, 2018 - Wiley Online Library
With their novel, insulin‐independent mechanism, sodium‐glucose cotransporter‐2 (SGLT2)
inhibitors are a major turning point in the management of type 2 diabetes mellitus. At …

The impact of glucose-lowering drugs on sarcopenia in type 2 diabetes: current evidence and underlying mechanisms

E Massimino, A Izzo, G Riccardi, G Della Pepa - Cells, 2021 - mdpi.com
The age-related decrease in skeletal muscle mass together with the loss of muscle power
and function is defined sarcopenia. Mounting evidence suggests that the prevalence of …

Sodium–glucose co‐transporter 2 inhibitors in heart failure: beyond glycaemic control. A position paper of the Heart Failure Association of the European Society of …

PM Seferović, G Fragasso, M Petrie… - European journal of …, 2020 - Wiley Online Library
Heart failure (HF) is common and associated with a poor prognosis, despite advances in
treatment. Over the last decade cardiovascular outcome trials with sodium–glucose co …

Effect of SGLT2 inhibitors on body composition, fluid status and renin–angiotensin–aldosterone system in type 2 diabetes: a prospective study using bioimpedance …

A Schork, J Saynisch, A Vosseler, BA Jaghutriz… - Cardiovascular …, 2019 - Springer
Background SGLT2-inhibitors are potent antihyperglycemic drugs for patients with type 2
diabetes and have been shown to reduce body weight. However, it is unclear which body …

Anti‐diabetic drugs and sarcopenia: emerging links, mechanistic insights, and clinical implications

X Zhang, Y Zhao, S Chen… - Journal of cachexia …, 2021 - Wiley Online Library
Sarcopenia, characterized by loss of skeletal muscle mass, quality, and strength, has
become a common hallmark of ageing and many chronic diseases. Diabetes mellitus …

[HTML][HTML] A review of the effects of glucagon-like peptide-1 receptor agonists and sodium-glucose cotransporter 2 inhibitors on lean body mass in humans

JA Sargeant, J Henson, JA King… - Endocrinology and …, 2019 - synapse.koreamed.org
Weight loss is an important goal in the management of several chronic conditions, including
type 2 diabetes mellitus, and pharmacological therapies that aid weight loss are appealing …

Diabetes pharmacotherapy and effects on the musculoskeletal system

E Kalaitzoglou, JL Fowlkes, I Popescu… - … research and reviews, 2019 - Wiley Online Library
Persons with type 1 or type 2 diabetes have a significantly higher fracture risk than age‐
matched persons without diabetes, attributed to disease‐specific deficits in the …

Canagliflozin for Japanese patients with chronic heart failure and type II diabetes

A Sezai, H Sekino, S Unosawa, M Taoka… - Cardiovascular …, 2019 - Springer
Background Reports that sodium glucose cotransporter 2 inhibitors decrease cardiovascular
death and events in patients with diabetes have attracted attention in the cardiology field …

Amelioration of fatty liver index in patients with type 2 diabetes on ipragliflozin: an association with glucose-lowering effects

T Takase, A Nakamura, H Miyoshi, C Yamamoto… - Endocrine …, 2017 - jstage.jst.go.jp
Amelioration of fatty liver index in patients with type 2 diabetes on ipragliflozin: an
association with glucose-lowering effect Page 1 2017, 64 (3), 363-367 NONALCOHOLIC …

Ipragliflozin, a sodium–glucose cotransporter 2 inhibitor, reduces bodyweight and fat mass, but not muscle mass, in Japanese type 2 diabetes patients treated with …

H Inoue, K Morino, S Ugi… - Journal of diabetes …, 2019 - Wiley Online Library
Abstract Aims/Introduction Sodium–glucose cotransporter 2 inhibitors reduce bodyweight
(BW) by creating a negative energy balance. Previous reports have suggested that this BW …