Lipid and carbohydrate homeostasis in higher organisms is under the control of an
integrated system that has the capacity to rapidly respond to metabolic changes. The …

Peroxisome proliferator-activated receptors (PPARs) compose a family of nuclear receptors
that mediate the effects of lipidic ligands at the transcriptional level. In this review, we …

A large body of data gathered over the past couple of years has identified the peroxisome
proliferator-activated receptors (PPAR) α, γ, and β/δ as transcription factors exerting …

Binding to helix 12 of the ligand-binding domain of PPARγ is required for full agonist activity.
Previously, the degree of stabilization of the activation function 2 (AF-2) surface was thought …

The nuclear receptor superfamily is composed of transcription factors that positively and
negatively regulate gene expression in response to the binding of a diverse array of lipid …

Coronary heart disease remains a major cause of worldwide morbidity and mortality despite
therapeutic advances that control many risk factors such as low-density lipoprotein …

Nonalcoholic steatohepatitis (NASH) is a severe form of nonalcoholic fatty liver disease
(NAFLD) characterized by liver steatosis, inflammation, and hepatocellular damage. NASH …

Metabolic syndrome (MS) remains one of the leading causes of mortality in Western
societies and has become a major public health challenge worldwide. 1 The term metabolic …

Chirality is a key factor for the safety and efficacy of many drug products. The production of
single enantiomers of drug intermediates has become increasingly important in the …

Evidence suggests that diabetes and cardiovascular disease (CVD) may share an
underlying cause (s), a theory known as the 'common soil'hypothesis. Insulin resistance is …