The genetic diversity of Trypanosoma cruzi, the protozoan agent of Chagas disease, is
widely recognized. At present, T. cruzi is partitioned into seven discrete typing units (DTUs) …

The complexity of host–pathogen interactions often leads to distinct clinical outcomes upon
infection with different pathogen strains. In this Review, we explore the interactions between …

Enteric-associated neurons (EANs) are closely associated with immune cells and
continuously monitor and modulate homeostatic intestinal functions, including motility and …

Chagas disease is caused by infection with the protozoan Trypanosoma cruzi, and although
over 100 years have passed since the discovery of Chagas disease, it still presents an …

Chagas disease caused by Trypanosoma cruzi remains an important neglected tropical
disease and a cause of significant morbidity and mortality. No longer confined to endemic …

Chagas disease is a chronic systemic infection transmitted by Trypanosoma cruzi. Its life
cycle consists of different stages in vector insects and host mammals. Trypanosoma cruzi …

The definition of a biomarker provided by the World Health Organization is any substance,
structure, or process that can be measured in the body, or its products and influence, or …

In Chagas disease, CD8+ T-cells are critical for the control of Trypanosoma cruzi during
acute infection. Conversely, CD8+ T-cell accumulation in the myocardium during chronic …

Trypanosoma cruzi, the protozoan causative of Chagas disease (ChD), exhibits striking
genetic and phenotypic intraspecific diversity, along with ecoepidemiological complexity …

This study was designed to investigate whether the expression of interleukin 17 (IL-17) is
associated with the indeterminate or cardiac clinical forms of Chagas disease and whether …