Arousal may be understood on a spectrum, with excessive sleepiness, cognitive dysfunction,
and inattention on one side, a wakeful state in the middle, and hypervigilance, panic, and …

Changes in cognition, affect, and brain function combine to promote a shift in the nature of
mentation in older adulthood, favoring exploitation of prior knowledge over exploratory …

Animal and human imaging research reported that the presence of cortical Alzheimer's
Disease's (AD) neuropathology, beta-amyloid and neurofibrillary tau, is associated with …

The locus coeruleus (LC) is a small brainstem structure located in the lower pons and is the
main source of noradrenaline (NA) in the brain. Via its phasic and tonic firing, it modulates …

The earliest abnormality associated with Alzheimer's disease (AD) is the presence of
persistently phosphorylated pretangle tau in locus coeruleus (LC) neurons. LC neuron …

The locus coeruleus (LC) has long been underappreciated for its role in the pathophysiology
of Alzheimer's disease (AD), Parkinson's disease (PD), and other neurodegenerative …

Locus coeruleus (LC) is severely affected in Parkinson's Disease (PD). However, alterations
in LC-related resting-state networks (RSNs) in PD remain unclear. We used resting-state …

Background: Despite growing evidence regarding the association between exercise training
(ET) and functional brain network connectivity, little is known about the effects of ET on large …

Background Atypical activity in the salience network (SN) and default mode network (DMN)
has been previously reported in individuals with autism spectrum disorder (ASD). However …

The locus coeruleus (LC), our main source of norepinephrine (NE) in the brain, declines with
age and is a potential epicentre of protein pathologies in neurodegenerative diseases (ND) …