Consensus guidelines for the use and interpretation of angiogenesis assays
The formation of new blood vessels, or angiogenesis, is a complex process that plays
important roles in growth and development, tissue and organ regeneration, as well as …
important roles in growth and development, tissue and organ regeneration, as well as …
Antifibrotic therapy for idiopathic pulmonary fibrosis: time to treat
TM Maher, ME Strek - Respiratory research, 2019 - Springer
Idiopathic pulmonary fibrosis (IPF) is a progressive disease with a dismal prognosis. The
average life expectancy of untreated patients with IPF is only 3 to 4 years. Decline in forced …
average life expectancy of untreated patients with IPF is only 3 to 4 years. Decline in forced …
Nintedanib for systemic sclerosis–associated interstitial lung disease
O Distler, KB Highland, M Gahlemann… - … England Journal of …, 2019 - Mass Medical Soc
Background Interstitial lung disease (ILD) is a common manifestation of systemic sclerosis
and a leading cause of systemic sclerosis–related death. Nintedanib, a tyrosine kinase …
and a leading cause of systemic sclerosis–related death. Nintedanib, a tyrosine kinase …
[HTML][HTML] Therapeutic effect of Sirtuin 3 on ameliorating nonalcoholic fatty liver disease: the role of the ERK-CREB pathway and Bnip3-mediated mitophagy
Increased mitochondrial damage is related to the progression of a diet-induced nonalcoholic
fatty liver disease. The aim of our study is to investigate the role of Sirtuin 3 (Sirt3) in treating …
fatty liver disease. The aim of our study is to investigate the role of Sirtuin 3 (Sirt3) in treating …
Fibrosing interstitial lung diseases: knowns and unknowns
V Cottin, L Wollin, A Fischer… - European …, 2019 - Eur Respiratory Soc
Patients with certain types of fibrosing interstitial lung disease (ILD) are at risk of developing
a progressive phenotype characterised by self-sustaining fibrosis, decline in lung function …
a progressive phenotype characterised by self-sustaining fibrosis, decline in lung function …
BI 1015550 is a PDE4B inhibitor and a clinical drug candidate for the oral treatment of idiopathic pulmonary fibrosis
FE Herrmann, C Hesslinger, L Wollin… - Frontiers in …, 2022 - frontiersin.org
The anti-inflammatory and immunomodulatory abilities of oral selective phosphodiesterase
4 (PDE4) inhibitors enabled the approval of roflumilast and apremilast for use in chronic …
4 (PDE4) inhibitors enabled the approval of roflumilast and apremilast for use in chronic …
Inhaled treprostinil and forced vital capacity in patients with interstitial lung disease and associated pulmonary hypertension: a post-hoc analysis of the INCREASE …
Background INCREASE was a randomised, placebo-controlled, phase 3 trial that evaluated
inhaled treprostinil in patients with interstitial lung disease (ILD) and associated pulmonary …
inhaled treprostinil in patients with interstitial lung disease (ILD) and associated pulmonary …
[图书][B] Microcomputed tomography: methodology and applications
SR Stock - 2019 - taylorfrancis.com
MicroComputed Tomography has become the gold standard for studying 3D microscopic
structures nondestructively, and this book provides up-to-date coverage of the modality. The …
structures nondestructively, and this book provides up-to-date coverage of the modality. The …
ER–mitochondria microdomains in cardiac ischemia–reperfusion injury: a fresh perspective
The mitochondrial and endoplasmic reticulum (ER) homeostasis is pivotal to the
maintenance of an array of physiological processes. The physical contact and association …
maintenance of an array of physiological processes. The physical contact and association …
Differential effects of Nintedanib and Pirfenidone on lung alveolar epithelial cell function in ex vivo murine and human lung tissue cultures of pulmonary fibrosis
M Lehmann, L Buhl, HN Alsafadi, S Klee… - Respiratory …, 2018 - Springer
Background Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease. Repetitive
injury and reprogramming of the lung epithelium are thought to be critical drivers of disease …
injury and reprogramming of the lung epithelium are thought to be critical drivers of disease …