Glioblastoma (GBM) is the most common primary malignant brain tumor in adults and has an
exceedingly low median overall survival of only 15 months. Current standard-of-care for …

The high mobility group protein 2 (HMGA2) regulates gene expression by binding to AT-rich
regions of DNA. Akin to other DNA architectural proteins, HMGA2 is highly expressed in …

Circular RNAs (circRNAs) are highly expressed in the central nervous system and are
involved in the regulation of physiological and pathophysiological processes. However, the …

Despite advances in neurosurgical techniques and radio-/chemotherapy, the treatment of
brain tumors remains a challenge. This is particularly true for the most frequent and fatal …

Atherosclerosis is characterized by the plaque formation that restricts intraarterial blood flow.
The disturbed blood flow with the associated oscillatory stress (OS) at the arterial curvatures …

Chronic inflammation is involved in the onset and development of many diseases, including
obesity, atherosclerosis, type 2 diabetes, osteoarthritis, autoimmune and degenerative …

Abstract Interleukin-6 (IL-6) is a prototypical cytokine with functional pleiotropy and plays an
important role in host defense. When infections or tissue injuries occur, IL-6 is promptly …

Abstract Interleukin-6 (IL-6) is a cytokine present in tumor microenvironment. Elevated level
of IL-6 is associated with cancer cell proliferation, angiogenesis and metastasis through …

Inflammation is an essential component of several respiratory diseases, such as chronic
obstructive pulmonary disease (COPD), asthma and acute respiratory distress syndrome …

Rationale: Peripheral nerve injury is common in clinic, which leads to severe atrophy and
dysfunction of the denervated muscles, but the underlying mechanism is not fully …