Nucleosome assembly following DNA replication, DNA repair and gene transcription is
critical for the maintenance of genome stability and epigenetic information. Nucleosomes …

Stability and function of eukaryotic genomes are closely linked to chromatin structure and
organization. During cell division the entire genome must be accurately replicated and the …

Recent studies have identified a Lys 27-to-methionine (K27M) mutation at one allele of
H3F3A, one of the two genes encoding histone H3 variant H3. 3, in 60% of high-grade …

Set2-mediated methylation of histone H3 at Lys 36 (H3K36me) is a co-transcriptional event
that is necessary for the activation of the Rpd3S histone deacetylase complex, thereby …

Hepatic glucose production (HGP) maintains blood glucose levels during fasting but can
also exacerbate diabetic hyperglycemia. HGP is dynamically controlled by a signaling …

The maintenance of genome integrity is essential for organism survival and for the
inheritance of traits to offspring. Genomic instability is caused by DNA damage, aberrant …

Eukaryotic genomes are packaged into chromatin, a highly organized structure consisting of
DNA and histone proteins. All nuclear processes take place in the context of chromatin …

The many factors that control chromatin biology play key roles in essential nuclear functions
like transcription, DNA damage response and repair, recombination, and replication and are …

FACT is a roughly 180kDa heterodimeric protein complex important for managing the
properties of chromatin in eukaryotic cells. Chromatin is a repressive barrier that plays an …

Methylation of histone H3 lysine 4 (H3K4me) is an evolutionarily conserved modification
whose role in the regulation of gene expression has been extensively studied. In contrast …