Insulin and insulin resistance in Alzheimer's disease
A Sędzikowska, L Szablewski - International journal of molecular sciences, 2021 - mdpi.com
Insulin plays a range of roles as an anabolic hormone in peripheral tissues. It regulates
glucose metabolism, stimulates glucose transport into cells and suppresses hepatic glucose …
glucose metabolism, stimulates glucose transport into cells and suppresses hepatic glucose …
Nanoparticle–liver interactions: Cellular uptake and hepatobiliary elimination
99% of administered nanoparticles will accumulate and sequester in the liver after
administration into the body. This results in reduced delivery to the targeted diseased tissue …
administration into the body. This results in reduced delivery to the targeted diseased tissue …
SYK coordinates neuroprotective microglial responses in neurodegenerative disease
Recent studies have begun to reveal critical roles for the brain's professional phagocytes,
microglia, and their receptors in the control of neurotoxic amyloid beta (Aβ) and myelin …
microglia, and their receptors in the control of neurotoxic amyloid beta (Aβ) and myelin …
Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity
Extracellular interaction between programmed death ligand-1 (PD-L1) and programmed cell
death protein-1 (PD-1) leads to tumour-associated immune escape. Here we show that the …
death protein-1 (PD-1) leads to tumour-associated immune escape. Here we show that the …
Smooth muscle cell-driven vascular diseases and molecular mechanisms of VSMC plasticity
A Frismantiene, M Philippova, P Erne, TJ Resink - Cellular signalling, 2018 - Elsevier
Vascular smooth muscle cells (VSMCs) are the major cell type in blood vessels. Unlike
many other mature cell types in the adult body, VSMC do not terminally differentiate but …
many other mature cell types in the adult body, VSMC do not terminally differentiate but …
Altered proliferation and networks in neural cells derived from idiopathic autistic individuals
Autism spectrum disorders (ASD) are common, complex and heterogeneous
neurodevelopmental disorders. Cellular and molecular mechanisms responsible for ASD …
neurodevelopmental disorders. Cellular and molecular mechanisms responsible for ASD …
Glycogen synthesis and beyond, a comprehensive review of GSK3 as a key regulator of metabolic pathways and a therapeutic target for treating metabolic diseases
L Wang, J Li, L Di - Medicinal Research Reviews, 2022 - Wiley Online Library
Abstract Glycogen synthase kinase‐3 (GSK3) is a highly evolutionarily conserved
serine/threonine protein kinase first identified as an enzyme that regulates glycogen …
serine/threonine protein kinase first identified as an enzyme that regulates glycogen …
Inflammation and oxidative stress: the molecular connectivity between insulin resistance, obesity, and Alzheimer's disease
Type 2 diabetes (T2DM), Alzheimer's disease (AD), and insulin resistance are age‐related
conditions and increased prevalence is of public concern. Recent research has provided …
conditions and increased prevalence is of public concern. Recent research has provided …
Protein kinase C controls lysosome biogenesis independently of mTORC1
Y Li, M Xu, X Ding, C Yan, Z Song, L Chen… - Nature cell …, 2016 - nature.com
Lysosomes respond to environmental cues by controlling their own biogenesis, but the
underlying mechanisms are poorly understood. Here we describe a protein kinase C (PKC) …
underlying mechanisms are poorly understood. Here we describe a protein kinase C (PKC) …
Ionizing radiation-induced DNA damage, response, and repair
WL Santivasi, F Xia - Antioxidants & redox signaling, 2014 - liebertpub.com
Significance: Ionizing radiation (IR) is an effective and commonly employed treatment in the
management of more than half of human malignancies. Because IR's ability to control …
management of more than half of human malignancies. Because IR's ability to control …