Genetic analyses have shaped much of our understanding of cancer. However, it is
becoming increasingly clear that cancer cells display features of normal tissue organization …

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy caused by the
accumulation of genomic lesions that affect the development of T cells. For many years, it …

Patient-derived xenografts (PDXs) have become a prominent cancer model system, as they
are presumed to faithfully represent the genomic features of primary tumors. Here we …

In acute myeloid leukaemia (AML), the cell of origin, nature and biological consequences of
initiating lesions, and order of subsequent mutations remain poorly understood, as AML is …

Cancers evolve by a reiterative process of clonal expansion, genetic diversification and
clonal selection within the adaptive landscapes of tissue ecosystems. The dynamics are …

Human cancers, including breast cancers, comprise clones differing in mutation content.
Clones evolve dynamically in space and time following principles of Darwinian evolution …

The maintenance and repair of many adult tissues are ensured by stem cells (SCs), which
reside at the top of the cellular hierarchy of these tissues. Functional assays, such as in vitro …

Cancer research relies on model systems, which reflect the biology of actual human tumours
to only a certain extent. One important feature of human cancer is its intra-tumour genomic …

Intratumoral heterogeneity arises through the evolution of genetically diverse subclones
during tumor progression. However, it remains unknown whether cells within single genetic …

Efforts to identify and annotate cancer driver genetic lesions have been focused primarily on
the analysis of protein-coding genes; however, most genetic abnormalities found in human …