The roles of phosphoinositide-specific phospholipase C (PLC) have been extensively
investigated in diverse cell lines and pathological conditions. Among the PLC isozmes …

Myotonic dystrophy (DM) is a multisystemic disorder caused by microsatellite expansion
mutations in two unrelated genes leading to similar, yet distinct, diseases. DM disease …

As a member of the phospholipase family, phospholipase C beta 1 (PLCB1) is involved in
phospholipid hydrolysis and is frequently upregulated in human cancer. However, little is …

Myotonic dystrophy type 1 (DM1) is a CTG microsatellite expansion (CTGexp) disorder
caused by expression of CUGexp RNAs. These mutant RNAs alter the activities of RNA …

Myogenesis is defined as growth, differentiation and repair of muscles where cell fusion of
myoblasts to multinucleated myofibers is one major characteristic. Other cell fusion events in …

Abstract Phosphoinositide-phospholipase C-β1 (PLC-β1) plays a crucial role in the initiation
of the genetic program responsible for muscle differentiation and osteogenesis. During …

Phosphoinositide-specific phospholipases C (PI-PLCs) are involved in signaling pathways
related to critical cellular functions, such as cell cycle regulation, cell differentiation, and …

Phosphatidylinositols (PIs) are responsible for several signaling pathways related to many
cellular functions, such as cell cycle regulation at different check-points, cell proliferation …

The existence of an independent nuclear inositide pathway distinct from the cytoplasmic one
has been demonstrated in different physiological systems and in diseases. In this prospect …

Phosphoinositide (PtdIns) signaling involves the generation of lipid second messengers in
response to stimuli in a receptor-mediated manner at the plasma membrane. In neuronal …