Neurons are specialized cells with a complex morphology that represent the functional unit
of the nervous system. They are generated in remarkable numbers, particularly in higher …

This review focuses on the role of the peripheral nervous system in cutaneous biology and
disease. During the last few years, a modern concept of an interactive network between …

Neurogenesis continues to occur in the adult mammalian hippocampus and is regulated by
both genetic and environmental factors. It is known that exposure to an enriched …

Brain-derived neurotrophic factor (BDNF) activates the receptor tropomyosin-related kinase
B (TrkB) with high potency and specificity, promoting neuronal survival, differentiation, and …

▪ Abstract Neurotrophins are a family of growth factors critical for the development and
functioning of the nervous system. Although originally identified as neuronal survival factors …

Brain-derived neurotrophic factor (BDNF), after activity-dependent secretion from neurons,
modulates critical nervous system functions. Recently, a variant in the human bdnf gene …

In the past 15 years numerous reports provided strong evidence that brain-derived
neurotrophic factor (BDNF) is one of the most important modulators of glutamatergic and …

The neurotrophins are best known for their ability to support neuronal survival and
differentiation, but a role in synapse formation and plasticity has recently emerged. For …

Neurotrophins are synthesized first as precursors, followed by maturation through proteolytic
removal of the" pro" region. Since pro-and mature neurotrophins elicit opposite functional …

Gain-of-function mutations in the housekeeping gene GARS1, which lead to the expression
of toxic versions of glycyl-tRNA synthetase (GlyRS), cause the selective motor and sensory …