Nonalcoholic fatty liver disease (NAFLD) is a burgeoning health problem worldwide and an
important risk factor for both hepatic and cardiometabolic mortality. The rapidly increasing …

Nonalcoholic Fatty Liver Disease (NAFLD) represents the leading cause of liver disease in
developed countries but its diffusion is currently also emerging in Asian countries, in South …

Hepatic fibrosis is a wound healing response to insults and as such affects the entire world
population. In industrialized countries, the main causes of liver fibrosis include alcohol …

Multiple etiologies of liver disease lead to liver fibrosis through integrated signaling networks
that regulate the deposition of extracellular matrix. This cascade of responses drives the …

The hepatic stellate cell has surprised and engaged physiologists, pathologists, and
hepatologists for over 130 years, yet clear evidence of its role in hepatic injury and fibrosis …

Chronic infection with hepatitis C virus (HCV) is a leading cause of liver-related morbidity
and mortality worldwide and predisposes to liver fibrosis and end-stage liver complications …

While non-alcoholic fatty liver disease (NAFLD) is highly prevalent (15% to 45%) in modern
societies, only 10% to 25% of cases develop hepatic fibrosis leading to cirrhosis, end-stage …

Transforming growth factor β (TGF-β) is the most potent and ubiquitous profibrogenic
cytokine, and its expression is increased in almost all the fibrotic diseases and in …

Administration of a methionine and choline deficient (MCD) diet to rodents causes
progressive fibrosing steatohepatitis pathologically similar to human metabolic …

Inflammation and oxidative stress are considered critical factors in the progression of
nonalcoholic fatty liver disease. Myeloperoxidase (MPO) is an important neutrophil enzyme …