Epilepsy is a chronic brain disease and, considering the amount of people affected of all
ages worldwide, one of the most common neurological disorders. Over 20 novel antiseizure …

Regulation of proteoglycan and glycosaminoglycan synthesis is critical throughout
development, and to maintain normal adult functions in wound healing and the immune …

Up to 40% of neurodevelopmental disorders (NDDs) such as intellectual disability,
developmental delay, autism spectrum disorder, and developmental motor abnormalities …

Despite clear technical superiority of genome sequencing (GS) over other diagnostic
methods such as exome sequencing (ES), few studies are available regarding the …

The domestic cat (Felis catus) numbers over 94 million in the USA alone, occupies
households as a companion animal, and, like humans, suffers from cancer and common and …

Hepatocyte apoptosis plays an essential role in the progression of nonalcoholic
steatohepatitis (NASH). However, the molecular mechanisms underlying hepatocyte …

Glycosaminoglycans (GAGs) including chondroitin sulfate, dermatan sulfate, and heparan
sulfate are covalently attached to specific core proteins to form proteoglycans, which are …

Epilepsy is a common neurological disorder characterized by recurrent and unprovoked
seizures due to neuronal hyperactivity. A large proportion of epilepsy cases begin during …

Biallelic genetic variants in N-acetylneuraminic acid synthase (NANS), a critical enzyme in
endogenous sialic acid biosynthesis, are clinically associated with neurodevelopmental …

The use of zebrafish as a model organism is gaining evidence in the field of epilepsy as it
may help to understand the mechanisms underlying epileptic seizures. As zebrafish assays …