Behavioural, cellular and molecular studies have revealed significant effects of enriched
environments on rodents and other species, and provided new insights into mechanisms of …

Since the identification of the causative gene in Huntington's disease (HD), a number of
animal models of this disorder have been developed. A frequently asked question is: which …

The striatum, a major component of the basal ganglia, performs multiple functions including
control of movement, reward, and addiction. Dysfunction and death of striatal neurons are …

The primary somatosensory barrel cortex processes tactile vibrissae information, allowing
rodents to actively perceive spatial and textural features of their immediate surroundings …

Many lines of evidence support a role for neuronal damage arising as a result of excessive
activation of glutamate receptors by excitatory amino acids in the pathogenesis of …

Environmental stimulation throughout development adjusts the neurobehavioral systems
involved in learning, memory and defensive responses. Environment-mediated phenotypic …

Since its initial conceptualisation, metaplasticity has come to encompass a wide variety of
phenomena and mechanisms, creating the important challenge of understanding how they …

Cognitive problems occur in asymptomatic gene carriers of Huntington's disease (HD), and
mouse models of the disease exhibit impaired learning and substantial deficits in the …

Notch signaling in the nervous system has been most studied in the context of cell fate
specification. However, numerous studies have suggested that Notch also regulates …

Background Accurate and reproducible behavioral tests in animal models are of major
importance in the development and evaluation of new therapies for central nervous system …